| Objiective To study the expressions of CD147, MMP-9 and VEGF in renal cell carcinoma, and their correlation with tumor growth, tumor invasion and metastasis. Methods The expression of CD147, MMP-9 and VEGF were detected immunohistochemically SP method in tissue from the carcinoma (RCC , n=107) and normal renal tissue (n=10). The relationships between the expression and clinical pathology were analyzed, and correlation among CD147, MMP-9 and VEGF was studied. Results Expressions of CD147, MMP-9 and VEGF in RCC were significantly higher than that of normal renal tissue (P<0.05), which were not related to pathological type ( P>0.05), but related to clinical staging (P<0.05). A positive correlation among CD147, MMP-9 and VEGF was observed (P<0.05). Furthermore, the expression of CD147 was significantly associated with the tumor size, clinical stage and distant metastasis (P<0.05), but not with age and gender (P>0.05). Conclusion CD147, MMP-9 and VEGF correlate significantly with aggressiveness and invasion in RCC, suggesting of expression of CD147, MMP-9 and VEGF may be biological indexes in detecting tumor growth, invasion and metastasis of RCC.
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