Effects Of Lidocaine On Cardoprotection Of Sevoflurane Postconditioning

Objective:Postischemic administration of volatile anesthetics activates ischemia-reperfusion injury salvage process and decreases myocardial damage. However,the mechanisms underlying anesthetic postconditioning and effects of lidocaine on it remain unclear.Here we report the cardioprotection of sevoflurane-induced postconditioning and the effects of lidocaine on it.Methods:Isolated perfused rat hearts were exposed to 40 min of ischemia followed by 1h of reperfusion.Volatile anesthetic postconditioning was induced by 15 min of 3vol%sevoflurane administered at the onset of reperfusion.In some experiments, lidocaine was coadministered with sevoflurane in different concentrations(2,10 and 20μg/ml).Infarct size was determined by dividing the total necrotic area of the left ventricle by the total left ventricular slice area(percent necrotic area).Results:Sevoflurane-induced postconditioning significantly improved postischemia functional recovery and decreased infarct size(47.3±5.6%in unprotected hearts vs 18.6±3.1%in anesthetic postconditioning,p＜0.05).Sevoflurane mediated cardioprotection was abolished by 20μg/ml lidocaine.Conclusion:sevoflurane-induced postconditioning effectively protected myocardium against reperfusion damage and its cytoprotection was reversed by 20μg/ml lidocaine.