| Objective:This study was designed to observe and evaluate the curative effect of the treatment of Shuyu Jiangni Tang United omeprazole and domperidone treat gastroesophageal reflux disease(GERD) which was the type of Gan Wei Bu He.To compared with the control group(omeprazole,domperidone ),was to explore further the mechanism of Shuyu Jiangni Tang in the aspect of theory and research.Methods:1.Selected 64 cases of patients with GERD,both in May 2007—2008 year in April in Chinese medicine hospital in Hubei Province to digest the case of internal medicine out-patient clinic,all cases are in line with August 25,1999 National esophageal reflux disease / reflux esophagitis workshop developed diagnostic criteria.Reference to the Ministry of Health People's Republic of China in 1997 by enacting the "traditional Chinese medicine clinical research of new drugs the first series of guiding principles" and "practical study of Chinese medicine of digestive diseases,"The type of TCM is Gan Wei Bu He (including the type of Gan Wei Yu Re ).In accordance with the statistical software,all cases were randomly divided,into observer group and control group which were 32 cases.Two groups in age,gender,disease duration and disease aspects of the difference was not significant(P＞0.05),and comparable. 2.Observer Group to be given orally Shuyu Jiangni Tang:Cuzhichaihu 9g,Zhike 10g,Chenpi 12g,Xiangfu 12g,Chuanxiong 10g,Baichao 15g,Jiangban xia 10g,Huanglian 6g,Huangqin 9g,Baizhu 9g,Haipiaoxiao 25g,Zhigancao 6g, addition and subtraction with the disease.Taking traditional herb,a daily, morning and evening service hours.On this basis,taking western medicine omeprazole 20mg,two times a day,and Domperidone 10mg(fasting for 15 minutes),three times a day.One course of treatment for four weeks,a total of two courses taken.Control group,oral omeprazole,domperidone,guilty with the observation group.Two groups of patients to quit smoking during treatment were temperance,not into the greasy and irritating food,raise the bed 15—20cm,the attention of not eating before going to bed,In addition to the above do not take other drugs with the disease-related drugs.Close observation during the clinical symptoms,one week out-patient referral, recording symptoms,signs Change,the treatment of endoscopic inspection before and after one meeting,in accordance with the domestic esophagitis grading criteria to determine the degree of inflammation level.During treatment were carried out security checks(general physical examination items,the three conventional laboratory tests,electrocardiogram,Liver and kidney function tests,possible adverse reactions) and efficacy of observation.After the treatment,6 months follow-up to observe the long-term effect.3.statistical analysis methods:statistical software SPSS17.0 data for analysis.Information on the use of Level Ridit analysis,count data using x~2 test,measurement data using t test.Results:1.Observer Group:the cure rate was 25.00%,total effective rate was 90.63%;control group:the cure rate was 15.63%,total effective rate was 84.38%.Differences between the two groups was statistically significant effect(P＜0.05),the integrated effect of the observation group than the control group.2.The two groups of patients with total score of symptoms of TCM difference were statistically significant(P＜0.01) between pre-treatment and after treatment,the observation group and control group can improve symptoms of TCM;Chinese medicine treatment in patients with symptoms of two groups of total score differences were significant(P＜0.01),the observation group of Chinese medicine to improve the symptoms of the total score is better than the control group.3.Observer Group recurrence rate was 21.88%,control group,the recurrence rate of 46.88%,relapse rates were significantly(P＜0.05),long-term effect of the observation group than the control group.Conclusion:Prompted this research Shuyu Jiangni Tang is safe and effective treatment of gastroesophageal reflux disease of the prescription,the Joint Western medicine omeprazole,domperidone integrated effect of the treatment of the disease,long-term effect is better than western medicine group.Its mechanism may be related to some aspects of the following:1.Increase the gastric peristalsis,and promote gastrointestinal emptying,anti-reflux, 2.Inhibit gastric acid,analgesic effect,3.Anti-inflammatory and antibacterial effects,the application of Traditional Chinese Medicine and Western Medicine United this disease,has achieved significant results,it is worthy of our further in-depth and summary.
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