Related Study On Serum And Tissue Cu Of Pregnancy Women In IUD

Objective:Through determine the copper content of uterus deciduas,embryo villus and blood serum,comparing with the content of the normal pregnancy women intended to terminate pregnancy,we investigate the tissue copper content if had an toxicity influence on offspring.Meanwhile analyze the characteristics of pregnancy women in Cu-IUD intended to terminate pregnancy,we explode the causes of Cu-IUD failure.Methods:With the method of random-controll clinical research,twenty-five pregnancy women in Cu-IUD intended to terminate pregnancy are experimental group,twenty-five normal pregnancy women intended to terminate pregnancy are control group.To determine the copper content of uterus deciduas,embryo villus and blood serum in experimental group and control group.And we take the careful analysis of characteristics of pregnancy women in Cu-IUD intended to terminate pregnancy,we explode the causes of Cu-IUD failure.Results:The copper content of uterus decidua,embryo villus and blood serum in experimental group respectively are 0.91±0.51mg/kg,0.72±0.50mg/kg,0.79±0.15 mg/L;the content of control group in uterus deciduas,embryo villus and blood serum are 0.57±0.21 mg/kg,0.46±0.21 mg/kg,0.71±0.15mg/L;To compare the copper content disparities in uterus deciduas and embryo villus between experimental group and control group,there are obvious differences.But the serum copper content has no difference between the two groups.At the same time,take the correlation analysis about the Cu content between serum and embryo villus,serum and uterus deciduas of control group,so is experimental group,the results have no difference,all of them have no relation.Of the related factors in Cu-IUD faiure,age,parity,the time of placement have correlation;whereas the position of the uterus has no correlation. Furthermore,the level of placement,the quality of follow-up also have the relationship with the IUD placement.Conclusion:Cu ion released from Cu-IUD only had an influence on the uterus,having no difference on the Cu metabolism all over the body.The local rising Cu content produced cell and reproduction toxicity,which will be researched further.