Correlation Of Metablic Parameters Of Non-Obesity Type 2 Diabetic Patients To Functions Of TAFI, PAI-1 And VWF

Objectives:To assess the effect of Thrombin-Activatable Fibrinolysis Inhibitor(TAFI),Plasminogen Activator Inhibitor-1(PAI-1),Vascular Von Willebrand factor(vWF) and Fibrinogen(Fib) on fibrinolytisis,coagulation and endothelial disfunction changes in non-obesity type 2 diabetic patients, and investigate the relationship between TAFI,PAI-1 and clinical parameters of metabolism,thereby hopefully to provide a new theory evidence for the early intervention of vascular injury and clinical treatment for non-obesity type 2 diabetic patients.Methods:The individuals confined to the enrolling criteria were grouped into three groups.Group 1 inculded 57 cases of non-obesity type 2 diabetic patients with vascular lesion;group 2 contained 39 ones of non-obesity type 2 diabetic patients without vascular lesion;enrolled 80 healthy individuals were regarded as normal control.The levels of plasma TAFI,PAI-1 and vWF were measured by immunosorbent assay(ELISA),and the level of fibrinogen (Fib) was checked by Clauss method.The changes of fasting blood glucose, glycosylated hemoglobin,fasting insulin,body mass index and lipid metabolism indicators were detected as well.By T-test and Pearson stastic methods,the differences between TAFI,PAI-1,vWF,Fib and the relationship between TAFI,PAI-1 and clinical metablic parameters were analyzed.Results:Compared with the plasmic levels of TAFI,PAI-1,vWF,Fib in normal control group,those in group 1 were obviously increased,which showed statistically significant(P＜0.01),TAFI,PAI-1,vWF,Fib in group 2 dramatically decreased with significant difference(P＜0.05).Compared with the plasmic levels of TAFI,PAI-1 in group 2,those in group 1 were obviously increased,which showed statistically significant(P＜0.05).Furthermore,the significantly positive correlations were found between plasmic TAFI level and serum fasting blood glucose levels,or serum glycosylated hemoglobin levels(r =0.29,P＜0.05;r=0.71,P＜0.01 respectively).Meanwhile,another positive correlation was also observed between the plasmic PAI-1 level and BMI(r= 0.33,P＜0.05).However,there was no relationship between the changes of plasma PAI-1 and TAFI levels(P＞0.05).Conclusion:The findings suggest that the coagulation activity could be enhanced in non-obesity type 2 diabetic patients accompanied by decreased activity of fibrinolysis.Therefore,the increased level of plasma TAFI is related with the long-term high blood sugar,it is a valuable marker to assess the deterioration of disease,and the fat accumulation is involved in the increased levels of PAI-1 in disease.