| Purpose:To investigate the character of the plasma content level of thrombin-activatable fibrinolysis inhibittor activity and antigen(TAFIa and TAFIAg),and the relativity between the plasma levels of TAFI and the cerebral stroke,which included ischemical stroke(IS) and incerebral hemorrhage(ICH).We discussed the issue for the first time at homes and overseas.And we tried to find the relation between the TAFI and the blood type.Methods:We had studied 228 stroke patients in department of neurology in our hospital,from March,2006 to June,2007.Among them,IS group included 110 cases and ICH group included 118 cases.The control group of 40 subbjects came from the healthy people in physical examination.The age and sex of the patients and the control cases were matching(p＞0.05).All of the sample came from vein.The samples of the patient were achieved in acute phase(less than 12 hours of the stroke onset), and the samples of control cases were collected in the morning of the empty stomach. The vein samples were analyzed by enzyme-linked immunosorbent assay(ELISA).Results:The results of ELISA showed that the plasma level of TAFIa in IS,ICH and control cases were 168.79±55.36 ng/ml,207.99±73.71 ng/ml and 126.43±31.88 ng/ml, and the TAFIAg's were 118.72±31.41μg/ml,127.51±37.59μg/ml and 100.63±25.28μg/ml,respectively.The level of TAFIa and TAFIAg in patient group was higher than control cases.There were significant difference between the two groups(p＜0.01).TAFI was one of the risk factors of stroke.And the ratio of the TAFI increase among stroke patients was higher than the healthy cases.The TAFIa of IS was 43.6%,ICH was 52.7%,control was 7.5%.The TAFIAg of IS was 36.5%,ICH was 20.1%,control was 8.7%.To assess stroke hazard,IS was 3 times of the control, and ICH was 7 times of the control.The ratio of TAFIa/TAFIAg was 1.776±0.762 and 1.578±0.473 in IS and ICH,respectively.Both were compared with the control (1.329±0.431,P＜0.001,P＜0.05).It was suggested that protein activity increased obviously.The increase level of TAFIa and TAFIAg had no relationship with other risk factors of the stroke,which included age,sex,diabetes,high blood pressure,etc. TAFI decreased when the patients went out of the hospital.Among the TAFIa increased patients,O-type blood were in the majority,50.0%(14/28) in IS,and 37.9%(22/58) in ICH.And Among the TAFIAg increased patients,B-type blood were in the majority,44.0%(22/50) in IS,and 31.3%(10/32) in ICH.Conclusions:The level of the IS and ICH rise significantly,and the higher TAFI was a risk factor not only in IS but also in ICH.And it has a litter higher frequency.We use it to evaluate the clinical risk of stroke.The level of TAFIAg and TAFIa increased simultaneously in stroke.So TAFI was one of the risk factors of stroke.We presumed the reason of the raise of TAFI was the acute reaction.The TAFI raise had definite relation with the blood type.In one word,the plasma content of TAFI had a good relation with stroke.It increased greatly the risk of stroke onset.
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