The Effection Of L-Arginine On Erythrocyte And Its Immune Function In Cardiac Surgery With Cardiopulmonary Bypass

Objective To study the effection of L-Arginine on Erythrocyte and its Immune Function in patients in Cardiac Surgery with Cardiopulmonary Bypass.Methods Thirty patients undergine elective valve replacement under CPB were randomly divided into two groups:L-Arginine group(L,n=15) and control group(C,n=15).Patiens with respiratory dysfunction, hepato-renal disease,blood disease,hyperlipoproteinemia or pulmonary hypertension were excluded.In group L patients received L-arginine 200 mg/kg which be added into 5%GS 50 ml through internal jugular vein with microinfusion pump at 99 ml/h speed before skin incision.In control group the patients received 5%GS 50 ml in which added nothing.Blood samples were taken from internal jugular vein before skin incision(t₁),30 min after initiation of CPB(t₂),at the end of CPB(t₃),at the end of operation(t₄),and 24h after operation(t₅),for determination of plasma malondialdehyde(MDA),free hemoglobin(FHb), red blood cell C3b receptor rosette rate(BRC-C3bRR),red blood cell immune complexes rosette rate(RBC-ICR).Results(1)MDA,FHb,RBC-ICR:No significant differences were found of in both group before skin incision.Levels of those in both groups increased significantly after CPB 30 minutes(P＜0.05),and them began to decrease at the end of CPB,but those of group L were lower than those of group C at all periods after beginning of CPB(P＜0.05).(2)RBC-C3bRR:RBC- C3bRR in both groups dereased significantly after CPB 30 minutes(P＜0.05),and them began to increase at the end of CPB,but RBC-C3bRR of group L were higher than RBC-C3bRR of group C at all periods after beginning of CPB(p＜0.05).Conclusion CPB causes damage and immunity depression of red blood cell.L-Arginine may protect red blood cell membrane and its immunity of patient during CPB.