The Expression And Significance Of Heparanase In Human Chronic Kidney Diseases Disease

Objective:To explore and disscuss the express division of Heparanase in the chronic nephropathy patient and its connection with clinical situation.Methods:checking the expressive level of Heparanase of acinus renis and nephric tubule of 36 chronic nephropathy patients through two stages of non-bioepiderm immunity class and SABC,then,making statistics analysis with the clinical information and patho of nephropathy.Results: 1.Heparanase takes on a little express in basal lamina and cells of acinus renis,intercapillary cells and cellula epithelialis nephric tubule of the nephros tissue in Contrastive Control Group. Contrasted with the normal Control Group,Hpa obviously increases in the affection nephridial tissue of the chronic nephropathy patient and appears in the acinus renis and nephric tubule,and contrasted with the Control Group,it has the statistics difference (P＜0.01).2.Contrasted with the Control Group,the expressive levle of Hpa in acinus renis and cellula epithelialis nephric tubule membranous nephropathy obviously steps up and is featured with statistics difference(P＜0.01);the first period of it rises with statistics difference(P＜0.01);the second period of acinus renis and cellula epithelialis nephric tubule membranous nephropathy obviously steps up with statistics difference(P＜0.01).But there is no distinction between the first and second period in terms of acinus renis and cellula epithelialis nephric tubule membranous nephropathy.3.Accrementition nephritis group: Contrasted with the Control Group,Hpa in acinus renis and cellula epithelialis nephric tubule membranous nephropathy obviously augments and its differences have statistics significance. With the aggravation of Cellular proliferation,Hpa of acinus renis and cellula epithelialis nephric tubule membranous nephropathy obviously increases,and it exists difference in the acinus renis and cellula epithelialis nephric tubule between the serious mesenterium accrementition and midrang mesenterium accrementition,between midrang mesenterium accrementition and ordinary mesenterium accrementition(p＜0.05),so does it between serious mesenterium accrementition and ordinary mesenterium accrementition (p＜0.01).4.Voltinism nephritis group:Contrasted with the Control Group,the expressive levle of Hpa in acinus renis and cellula epithelialis nephric tubule membranous nephropathy obviously augments and has statistics significance(P＜0.01).5.There is no contrastive statistics significance both in the acinus renis and in the express area and average gray scale of cellula epithelialis nephric tubule(p＞0.05 ).6.Dependablity between Hpa and clinical index: Hpa has positive correlation with 24 hour Urine protein quantitation r=0.5407,(p＜0.01), negative correlation with plasma-albumin r=-0.6948,(p＜0.01),which are statistics significance.It has no dependablity with serum creatinine,blood fat,immune globulin. Conclusions:1.Heparanase has a little express in basal lamina,cells of acinus renis, intercapillary cells and cellula epithelialis nephric tubule in the Control Group.Contrasted with the normal Control Group,Hpa obviously increases in the affection nephridial tissue of the chronic nephropathy patient and appears in the acinus renis and nephric tubule.2. Contrasted With the Control Group,Hpa in acinus renis and cellula epithelialis nephric tubule membranous nephropathy of MN patient notably strengthens,which is accordance with the increase of Urine protein and plays an important role in the abnormal express of Hpa and the formation of IMN nephronia pathological lesion and Urine protein.3.With the aggravation of accrementition nephritis tissue,Hpa predominently increases,which indicates that the acinus renis and cellula epithelialis nephric tubule Hpa are relevant with the nephrotic reactiveness.4.The express of Hpa has positive correlation with albuminuric extent,which demostrates that Hpa,one enzyme closely connected with albuminuria,has been arising the interests and reconstruction of the public and will become a new target of albuminuric therapy.