Study On Distribution Rules Of Clinical Symptom Of Traditional Chinese Medicine Of Hyperprolactinemia

BackgroundHyperprolactinemia(HPRL) is the condition of abnormal elevation in the blood serum prolactin level caused by various kind factors,which is common endocrine disturbance disease in young female.Clinical manifestations of HPRL are menstrual disorder,amenorrhea,galactorrhea,infertility,hyp-estrogen's state etc.HPRL is the main cause of menstrual disorder and anovulatory infertility in child-bearingwomen.HPRL's patients in infertility women are 19.5%and 5.0%in infertility men,so HPRL is close relation with genesis. Bromocryptine mesylate,the main drug used medication for west medical therapy at present,possess satisfactory clinical effect but many questions such as expensive price,some side effects,drug fast,prohibited by hypersensitiveness for clavus secalinus and easily recurring after drug withdrawal.Since its treatment obtained through concept of the whole body adjustment and determination of treatment based in patbogenesis obtained through differentiation of symptoms and signs,Tradition Chinese Medicine(TCM) represents its unique curative effect and dominance in treatment on HPRL. However,the disposition rule of differentiation of symptoms and signs for classification syndrome in TCM lack normative and objectivity,which constrains further research and promotion of TCM treatment for HPRL.Syndrome theory has provided feasibility guarantee for standardized and objective of TCM differentiation of symptoms and signs.Cluster analysis has provided a original view and method for standardized and objective research of TCM.ObjectivesThe purpose of this study is to explore distribution patterns of TCM syndromes differential of hyperprolactinemia,to suppply credible clinical evidence for establishment the objective,applicable and workable diagnostic code of traditional Chinese medicine syndrome,then to guide TCM treatment for hyperprolactinemia. MethodsUsing the method of combining literature research,expert consulation,clinical epidemiology investigation with mathematical statistics,to draw up information collection table of four diagnostic methods of TCM syndromes for HPRL,and to collect hospitalized and outpatient case information of HPRL from Hospital of TCM of Guangzhou in one year.Having set up base bank,entered data,we administrated the base bank and did statistical analysis with EPIdata3.2 and SPSS13.0,and get conclusion.Results1.The descriptive analysis of 165 cases' clinical message show: Psychological factor,such as irritable,depression,anxiety etc.,which tend to provoke Liver-depression,takes86.67%.It shows emotional upset,leading to Liver-depression,is one of the main etiological factors of hyperprolactinemia.Main clinical symptoms are:gas pain of breast,premenstrual chest distress and restless,gas pain in chest and hypochondrium etc.These symptoms are symptoms of Liver-depression.2.There are 165 cases consistent with standard.Through dialectic,the experts divided them into 6 patterns of syndrome:the syndrome of stagnation of QI due to depression of the liver(45cases) is the most syndrome pattern; the next is the syndrome of Kidney-asthenia and Liver-depression(41 cases),phlegmatic hygrosis(36cases),deficiency of Kidney-yin(25 cases);the syndrome of asdthenic splenonephro-yang(10cases),Liver-depression and blood stasis(8cases) is less.The disease has close relationship with Liver,Kidney,Spleen.3.165 clinical cases use K-Means cluster analysis for 3 categories: Liver-depression syndrome(74cases),syndrome of liver and kidney asthenia (50cases),syndrome of splenic asthenia and phlegmatic hygrosis (41cases).Liver-depression is the most pattern.The disease has close relationship with Liver,Kidney,Spleen.4.To the patient of infertility group of HPRL,front three patterns of syndrome in arrangement are:syndrome of Kidney-asthenia and Liver-depression,syndrome of deficiency of Kidney-yin,syndrome of stagnation of QI due to depression of the liver,in which the constituent ratio of cases of syndrome of Kidney-asthenia and Liver-depression and syndrome of deficiency of Kidney-yin is significant difference between two groups of infertility and already procreated.Conclusion1.It shows emotional upset,leading to Liver-depression,is one of the main etiological factors of hyperprolactinemia.2.The disease of HPRL has close relationship with Liver,Kidney,Spleen. Through dialectic,the experts divided them into 6 patterns of syndrome:the syndrome of stagnation of QI due to depression of the liver is the most syndrome pattern;the next is the syndrome of Kidney-asthenia and Liver-depression,phlegmatic hygrosis,deficiency of Kidney-yin;the syndrome of asdthenic splenonephro-yang,Liver-depression and blood stasis is less.165 clinical cases use K-Means cluster analysis for 3 categories:Liver-depression syndrome,syndrome of liver and kidney asthenia,syndrome of splenic asthenia and phlegmatic hygrosis.3.To the patient of infertility group of HPRL,front three patterns of syndrome in arrangement are:syndrome of Kidney-asthenia and Liver-depression,syndrome of deficiency of Kidney-yin,syndrome of stagnation of QI due to depression of the liver,in which the constituent ratio of cases of syndrome of Kidney-asthenia and Liver-depression and syndrome of deficiency of Kidney-yin is significant difference between two groups of infertility and already procreated.It shows the Kidney deficiency and stagnation of liver-QI are main pathogenesis of the infertility patient of HPRL.