| Backgrounds:Cirrhosis is a sort of common chronic,progressive,diffuse liver disease cause by the different causes of disease.The diffuse hyperplasia of fibrous tissue is produced Based on the liver cells in its extensive degeneration and Change,and the formation of regeneration nodules and false lobule Nodular regenerationandFalse lobular,leading the normal structures of hepatic lobule and the damage of vascular anatomic.With the lesions gradually progressing, liver failure,portal hypertension and a variety of complications happens at advanced stage which is high mortality.In our country,the majority of liver cirrhosis is resulted from the development of chronic hepatitis B,our new infected people in each year more than 1.5 million cases,about 10%to 20% develop into liver cirrhosis,about 5%to develop into liver cancer,it has great harm on the social,family end people's health.So far,our country is still takes the chronic viral hepatitis,liver cirrhosis as a serious disease which impact on the learning,the work and the of lives of our nation' s people. Chinese medicine practitioners believe that hepatitis,cirrhosis is mainly ascribed to blood stasis.blood stasis play an important role in the process of development of liver hepatitis to cirrhosis,but in different stage,it shows different syndrome.The TCM treatment gains the good results on the treatment of hepatitis and cirrhosis,but the effect of the treatment is lack of sufficient evidence of Evidence-Based Medicine.Objective:Explore the element distributing trait of classification of hepatic cirrhosis classification of hepatic cirrhosis which in its different periods of(Pre-clinical decompensated,clinical decompensated and cecompensated) and corphological changes of different(not obvious nodular regeneration,small nodules,the size of mixed nodular,macronodular).Methods:Adopt the research methods of clinical epidemiology and diagnostic test, subjects were divided into 68 cases of cirrhosis group(27 cases of pre-clinical decompensated group,28 cases of clinical decompensated group,13 case of decompensated group) and 83 cases of non-liver sclerosis group(60 cases of non-liver disease control group,23 cases of chronic hepatitis group). According to 7 elements of TCM syndrome:"yu","hygro-","hot","spleen asthenia","yin deficiency","yang deficiency" Which were extracted by pattern of syndrome of TCM.Morphological data was collected by using specialized digital equipment during the process of surgical operation,the outcome of the observation will be save as a form of picture.The information is entered into the computer,the establishment of the databases,data management,using statistical packages SPSS13.0 for data analysis,count data rate,compared with X~2 test;measurement data with mean±standard deviation;compared with t test;test level a = 0.05.Results:(1) General information:①orphology of alcoholic liver cirrhosis changes into Small nodules and the size of mixed nodular;hepatitis B cirrhosis distributing in all the change of morphology;hepatitis C cirrhosis changed by the macronodular;Schistosoma cirrhosis changed by small nodules;Cholestatic liver cirrhosis changed by small nodules;Budd-Chiari syndrome changed by the macronodular;Cryptogenic cirrhosis changed by the macronodular;"Alcoholic + Hepatitis B" changed by the macronodular.②There is no abnormal changes in morphology of the liver in non-liver diseases and chronic hepatitis group;the liver's surface is smooth.In 27 cases of pre-clinical decompensated group 70.37%for not obvious modular regeneration,25.93%for Small nodules and 1 cases of macronodular.for 3.7%, In 28 cases of clinical decompensated group,the changes of the liver morphological are mainly attributed to small nodules,small nodules and macronodular,53.57%for small nodules,25.00%for the size of mixed nodular, 21.43%for macronodular;In 13 cases of decompensated group,the changes of the liver morphological are mainly attributed to the changed of the size of mixed nodular and macronodular,76.92%for macronodular,23.08%for the size of mixed nodular.(2) From the morphology of different stages of liver cirrhosis with the pattern of syndrome of TCM elements of the relationship between the syndrome:①Distribution of the pattern of syndrome of TCM elements Distribution in Liver cirrhosis at different stages:In the pre-clinical syndrome compensatory group the proportion of order of pattern of syndrome of TCM element according to the following:" yu"(81.5%)>" spleen asthenia"(55.6%) >" hygro"(40.7%)>" heat"(33.3%)>" blood stasis"(14.8%);In the clinical syndrome group the proportion of order of pattern of syndrome of TCM element according to the following:"blood stasis"(82.1%)>" yu"(62.3%) >" hygro "(46.2%) >" heat"(32.1%) >" spleen asthenia"(23.0%) >" yang deficiency "(7.1%);In the Decompensated group the proportion of order of pattern of syndrome of TCM element according to the following:" blood stasis"(100%) >" hygro"(53.8%) >" spleen asthenia"(46.2%) >" heat"(30.8%) >" yu" (15.4%) >" yang deficiency"(15.4%)=" yin deficiency"(15.4%).②The distribution of pattern of syndrome of TCM element between Liver cirrhosis group and control group:In the Cirrhosis group the proportion of order of pattern of syndrome of TCM element according to the following:" yu"(62.7%) >" blood stasis"(57.4%) >" hygro"(45.6%) >" spleen asthenia"(41.2%) > " heat"(32.4%) >" yang deficiency"(5.9%)>" yin deficiency"(3.0%);In the hepatitis group the proportion of order of pattern of syndrome of TCM element according to the following:" hygro"(60.9%)>" yu"(47.8%)=" heat"(47.8%) > " spleen asthenia"(43.5%) >" blood stasis"(21.8%) >" yang deficiency" (0) =" yin deficiency"(0);In the non-liver disease group the proportion of order of pattern of syndrome of TCM element according to the following:" hygro"(60.0%) >" heat"(53.3%) >" yu"(41.7%) >" blood stasis"(40.0%) >" spleen asthenia "(10.0%) >" yang deficiency"(11.7%) >" yin deficiency"(0).③The distribution of pattern of syndrome of TCM element in Morphological changes of liver cirrhosis of different groups:In the not obvious odular regeneration group the proportion of order of pattern of syndrome of TCM element according to the following:" yu"(89.5%)>" spleen asthenia"(52.6%) >" hygro"(42.1%) >" heat"(31.6%) >" blood stasis"(10.5%) >" yang deficiency"(0) =" yin deficiency"(0);In the small nodules group the proportion of order of pattern of syndrome of TCM element according to the following:" yu"(63.6%)>" spleen asthenia"(50.0%)=" blood stasis"(50.0%) >" hygro"(40.9%) >" heat"(27.3%) >" yang deficiency"(9.0%)>" yin deficiency"(0);In the the size of mixed nodular group the proportion of order of pattern of syndrome of TCM element according to the following:" blood stasis "(100%)>" yu"(60.0%)>" hygro"(50.0%)=" heat"(50.0%)>" spleen asthenia "(10.0%) =" yin deficiency"(10.0%) >" yang deficiency"(0);In the Macronodular group the proportion of order of pattern of syndrome of TCM element according to the following:" blood stasis"(94.1%)>" hygro"(52.9%) >" spleen asthenia"(35.3%) >" yu"(29.4%) = " heat"(29.3%) >" yang deficiency"(11.8%)>" yin deficiency"(0).Conclusion:(1) According to the general data,the change of the different causes of lives cirrhosis are of diversity and complexity;It means:pre-clinical decompensated group→clinical decompensated group→decompensated group.with the progress of the disease,the change trait of the liver cirrhosis morphological showed asnot obvious odular regeneration→small nodules→small nodules→macronodular.(2) View of the relationship between the morphology of liver cirrhosis of different stages and elements of traditional Chinese medicine,it shows that:①In pre-clinical decompensated group,were all mainly ascribed to" yu"," spleen asthenia",and often to see the patients of morphology ofnot obvious odular regenerationand small nodules.We found that the rule of the develop and occurrence of the cirrhosis is just as below:pre-clinical decompensated group to " yu" the main→decompensated group to " blood stasis "the main;" blood stasis" is not only the important element of liver cirrhosis but also a outcome of the process of the liver cirrhosis," blood stasis" may be an important promoting factor in progress in the result of cirrhosis,still,"blood stasis" are play a leading role in the development of cirrhosis.②" wet" and " hot" is always go through the liver cirrhosis," wet "," hot" may be a progress factor to the development of the liver cirrhosis and deficiency zheng is suppose to be the reason why it persistent refractory. (3) In the course of the occurrence and development of the liver cirrhosis,the element of the pattern of syndrome of TCM are variety at different stage,In the advanced stage,deteriorated case has become more by the push of the " hygro" and" heat",In a word,treatment should be focused on different periods of time.
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