Investigation To The Change Of Content Of Serum Cardiac TroponinT (cTnT) And Serum CK In Rats Induced By Daunorubicin

Objective To explore the value of serum cardiac troponinT(cTnT) and serum creatine kinase isoenzyme(CK-MB) in diagnosing the myocardial damage induced by daunorubicin(DNR) by investigating the changes of serum cTnT and CK-MB content in the rats.Methods 20 male wistar rats were randomly divided into two groups: the daunorubicin(DNR) treatment group(10 cases) and the control group (10cases).The treatment group was given daunorubicin(DNR) 2.0mg/kg every 3 days for 6 times by tail vein injection.The control group was given normal saline 1.0ml/kg every 3 days for 6 times by tail vein injection.The content of serum CK-MB and cTnT were measured at 0,6,12,18day (accumulated dose of DNR:0,4,8,12 mg/kg)Results The content of serum CK-MB showed no significant change (P>0.05) in treatment group,while the content of serum cTnT increased (P<0.01).On the other hand,there was no significant change of serum cTnT and serum CK-MB in control group.Conclusion After administrating the daunorubicin(DNR) in rats,the change of cTnT was more significant comparing to the serum CK-MB.We can use cTnT as a clinic method to detect myocardial damage induced by daunorubicin.