Analysis Of Change Of Cerebral Hemodynamic After Intra-and Extracranial Stenting With CT Perfusion Imaging

OBJECTIVE: To explore the value of CT perfusion in evaluating the changes of cerebral perfusion after intracranial and extracranial arterial stenting.METHODS: CT perfusion was performed in 22 patients before and after stenting. Relative perfusion values (rCBF,rCBV,rTTP)of vascular territories (direct and indirect) were respectively calculated by comparing with values of a chosen region. Relative perfusion values of Pre-and postoperative were compared for two groups.RESULTS: There was significant difference between pro- and post stenting of rTTP in the blood territories of stenotic cerebrovascular (1.050±0.106 vs 1.005±0.078,t=-3.954, P<0.001). No significant difference was showed between pro- and post stenting of rTTP in the non-blood territories of stenotic cerebrovascular (1.031±0.171 vs 1.022±0.171, t=-1.619, P=0.112). There was no significant difference between pro- and post stenting of rCBF and rCBV in the blood territories of stenotic cerebrovascular (rCBF: 0.970±0.187 vs 0.984±0.156, t=0.724, P=0.472; rCBV: 0.982±0.148 vs 0.980±0.124, t=-0.186, P=0.853). No significant difference was showed between pro- and post stenting of rCBF and rCBV in the non-blood territories of stenotic cerebrovascular (rCBF: 0.928±0.119 vs 0.962±0.138, t=1.766, P=0.084; rCBV: 0.945±0.088 vs 0.961±0.099, t=1.216, P=0.230).CONCLUSIONS: 1. Intra-extracranial arterial stenting may significant improve the cerebrovascular hemodynamics in the patients with intra-extracranial arterial stenosis. 2. rTTP is a sensitive index in the reflection of Intra-extracranial cerebrovascular hemodynamics after Intra-extracranial stenting.