Evaluation Of Distraction Osteognesis Of Non-Vascularized Transport Disc Ultrastructural Characters

Objective: developing an experimental model to reconstruction dog's mandibular defects by distraction osteogenesis of nonvascularized trans- port disc,to study osteogenesis mechanism and biological mechanism of action in distraction osteognesis of nonvascularized transport disc.Mehthods: we select 6 adult dogs, developing an experimental model,randomized grouping;two dogs were respectively killed at different time points(1 week, 4weeks,12 weeks after consolidation).The regenerated bonewere observed by radiology and electron microscopy,detecting morphologyand structure which regenerated bone and the contact plane of regeneratedbone and transport disc.The mineral content was measured by electron di-spersive spectroscopy. Result:the mandibular defects were reconstructed successfully at the medial transport plates.X-ray and organ images confirm regenerated bone exhibited intramembranous ossification generally.It is observed that nonva- scularized transport disc were substituted by regenerated bone. The rege- nerated bone is similar in morphology .Structure and mineral of the rege-nerated bone content to normal bone.Conclusion:developing an experimental model to reconstruction dog's mandibular defects by distraction osteogenesis of nonvascularized trans-port disc in China and abroad for the first time.We also study osteogene-sis mechanism in distraction osteogenesis of nonvascularized transport disc. It is different that the osteogenesis mechanism in distraction osteognesis of nonvascularized transport disc and previous.The regenerated bone is m-embrane bone in distraction osteognesis of nonvascularized transport disc.The site of regenerated bone formed on lingual side of mandibular defect.