| Objective: Coronary heart disease is one of the important diseases harmful to human health, its traditional risk factors such as age , sex ,smoking , hypertension, diabetes, hypercholesterolemia, etc, have been know gradually. In recent years, albuminuria and hyperuricemia and other non-traditional factors become new coronary heart disease risk factors. The purpose of this study is to investigate the level of the serum uric acid and the urinary albumin concentration in patients with coronary heart disease, and to research the correlation between the two factors. We want to show the function of albuminuria and hyperuricemia in coronary heart disease and to provide theoretical basis for development of coronary heart disease.Methods: 80 patients with coronary heart disease, who came from the inpatients of 2th hospital affiliated with the HEBEI Medical University. All subjects had excluded: (1) Urinary system disease such as nephritis, nephritic syndrome, urinary tract infection (2) Cardiac insufficiency (3) Hypertension (SBP≥140mmHg and (or) DBP≥90mmHg) (4) The recent use medicine that could impact the urinary albumin, such as ACEI, ARB (5) Diabetes mellitus (6) malignant tumors, gout, liver and kidney dysfunction, blood system diseases, etc, that affect uric acid level. Venous blood on an empty stomach was collected immediately after hospital admission, the level of serum uric acid and urinary albumin excretion rate (UAER) were measured ,and meanwhile CHOL, TG, HDL, LDL, FPG were detected. Then, 80 CHD patients were divided into two groups according to UAER, UARE<20ug/min defined as negative, UAER≥20ug/min defined as positive. The all patients were divided into two groups: 46 patients in negative group (32 males and 14 females), with average age of (58.32±9.69) years; 34 patients in positive group (24 males and 10 females), with average of (59.17±9.03)years. The age, sex , BMI showed no difference between two groups. Compared with two group of serum uric acid level, analyzed the relevance of UAER and UA.Results: (1)The serum level of UA in albuminuria positive group[(396.32±31.64 )umol/L] were significantly higher than negative group[(332.89±30.05)umol/L] (P <0.01)(2) The data showed positive association between UA and UAER in patients with coronay heart disease (r=0.775,P <0.01). (3) the TG(2.34±1.10)mmol/L,LDL(2.58±0.94) mmol/L in albuminuria-positive group were higher than those( TG (1.61±0.84)mmol/L, LDL (2.23±0.96) mmol/L ) in negative group. HDL was lower than negative group ((1.11±0.34) mmol/L vs (1.30±0.26) mmol/L ) (P <0.05). 4. Adjusted TG, HDL,LDL, UA relative risk ratio 1.077, 95% CI 1.040～1.115 (P <0.01). Conclusion: The level of uric acid in CHD patients with albuminuria was significantly higher than that in CHD patients without albuminuria. The level of serum uric acid was positively correlated with UAER in the patients with coronary heart disease, UA could be regarded as an independent risk factor in CHD patients presents the albumin urine, CHD patients with high uric acid level were more vulnerable to kidney damage. |
PDF Full Text Request