Diagnosis Of Breast Lesion By Functional MR

Objective: To evaluate the clinical application value of Vibrant,DWI and 1HMRS techniques in the diagnosis of breast lesion.Methods: To analyze 58 cases of breast lesion proved by the operation MR plain scan, VIBRANT dynamic contrast enhancement (DCE), DWI (b=1000×10-3s/mm2) and 1HMRS scan were performed in all cases. The imageologically manifestation and the types of enhancing patterns were analyzed. The time-signal intensity curve and the ADC values of the lesion were measured in workstation AW4.2. The ADC values measured were analyzed statistically by using q-test, and the diagnosis threshold value was difinited.On 1HMRS the Choline peak were analyzed. The sensitivity, specificity and accuracy of each method were evaluated and the data of the combining application of the three examination methods was evaluated too.Results: 69 lesions were detected in the 58 patients, including 49 benign lesions and 20 malignant tumors. All the cases were verified by pathology. The upper bound of the confidence interval of the malignant tumors'ADC value is choosed as the diagnosis threshold value. When ADC value is set as 1.016×10^-3s/mm²,sensitivity to the malignant tumors is 80.0% and specificity is 88.9%;sensitivity to the benign lesions is 89.8% and specificity is 93.6%; accuracy is 87.0%.On VIBRANT, sensitivity to the malignant tumors is 95.0% and specificity is 79.2%;sensitivity to the benign lesions is 89.8% and specificity is 97.8%; accuracy is 91.3%. On 1HMRS, sensitivity to the malignant tumors is 45.0% and specificity is 81.8%;sensitivity to the benign lesions is 67.3% and specificity is 78.6%; accuracy is 60.9%.when the three examination methods were combined, sensitivity to the malignant tumors is 95.0% and specificity is 82.6%;sensitivity to the benign lesions is 91.8% and specificity is 97.8%; accuracy is 92.8%. Conclusion: The combining application of the three examination methods will further increase the accurate diagnosis of breast lesion, yet there were overlapping in the MRI features of some benign and malignant breast lesions.