Research On Corneal Haze After LASEK

Part one: Features associated with occurrence of subepithelial corneal Haze after laser subepithelial keratomileusisObjective: To explore factors which lead to occurrence of subepithelial corneal Haze after laser subepithelial keratomileusis (LASEK).Methods: LASEK was performed on 202 eyes of 106 patients between Jan, 2006 and Jun, 2006 in our hospital. The patient data were evaluated retrospectively included left eye or right eye, sex, age, preoperative intraocular press, preoperative spherical equivalent refraction (SE), preoperative central corneal thickness and history of corneal contact lens. The data was analyzed using Logistic Regression method.Results: Follow-up results (with a mean follow-up time of 1.2 years ranging from half year to 2 year) showed that the occurrence rate of Haze was 10%. SE was associated with the occurrence of Haze.Conclusion: Severe spherical equivalent refraction is associated with a higher occurrence rate of Haze in myopic patients. Part two: The clinical study of applying mitomycin C in LASEKObjective: To observe the effect of mitomycin C in LASEK surgery.Methods: The left and right of eyes of 150 patients was randomly divided into two groups, 0.02% MMC sponge was put on to the cornea ablation area in 1 minutes during the operation in 150 eyes of MMC group; BBS sponge was put on to the cornea ablation area in 1 minutes during the operation in 150 eyes of the control group. Regular follow-up was done to observe the haze formation, cornea epithelium healing time, the recovery of visual acuity and diopter of the two groups.Results: Postoperative 3 month and 6 month the haze in MMC group is lighter than that of control group (P<0.05). Postoperative 6 month the visual acuity recovery in MMC group is better than that of control group (P<0.05).There is no difference of ocular irritation symptom, corneal epithelium healing time, and diopter between the control group and MMC group (P>0.05).Conclusion: The application of 0.02% MMC during LASEK operation could reduce the formation of haze. There is no side effect.