Effect Of Shuxuetong On Plasma PAI-1 And D-Dimer In Type2 Diabetic Patients With Coronary Heart Disease

Objective:To investigate the Effects and mechanism of Shuxuetong on type2 diabetic patients with coronary heart disease.Methods:The 120 type2 diabetic patients with coronary heart disease patients were randomly divided into treatment group and control group:the 60 of them were treated with routine western medicine (control group)and another 60 patients(treatment group)were treated with Shuxuetong on the base of routine medicine for 14 days. PAI-1, DD, PT,APTT,INR level were examined and angina symptoms and ECG ST-T were appraised at the following time points:before and after the therapy.Results: The levels of PAI-1 decreased significantly (P< 0.05)in the treatment group; PT,APTT,INR prolonged in the treatment group(P< 0.05);the DD level of 25% patients in the treatment group increased,75% of them decreased. PAI-1, DD,PT,APTT,INR in the patients of control group changed nonsense, the angina symptoms and ECG ST-T in the treatment group improved significantly than in the control group. There was no anaphylaxis or haemorrhage during the experiment in both two groups. Conclusion: In type2 diabetic patients with coronary heart disease, PAI-1 could be reduced, PT, APTT, INR could be prolonged and the angina symptoms and ECG ST-T could be improved by using Shuxuetong. The study indicated that the coagulation and fibrinolysis system of type2 diabetic patients with coronary heart disease were improved safely by using Shuxuetong.