Changes Of Plasma ET, FBG From Patient Acute Coronary Syndrome ACS And The Effect Of Shuxuetong

ACS is composed of STAMI, NSTAMI and UA. For ACS always results in the death or deformity, the attention is increasing. The mechanism and forecast of Hazard from Coronary artery is the hotspot. However the conclude is not clear. The report on the vein biology study of ACS is increasing. Per phase of ACS accrues with ED, the dysfunction of endodermis is the key step of CASET and FBG When ACS patient accrues the evident height of ED, ET and FBG, the Plasma ET and FBG of ACS patient can reflect the dysfunction of endodermis. Hirudin curing ACS can evident decreases ET and FBG, heighten endodermis function. The relative reports are very little, so this study wants to determine both the ET and FBG of the ACS patient prior and after treatment, discuss the value of ET and FBG in ACS and the effect of endodermis function of Hirudin.Method:Select 68 coronary heart disease(CHD) patient confirmed by coronary arteriography departing two teams:1. Comparison Team: stable angina team(SA), 26 cases, only coronary arteriography, routine nitrates medication, aspirin.2. Espial Team: ACS team, 42 cases, stochastic departing into two teams1) LM\A/H Team: 22 cases, use LMWH based on the treatment of Comparison Team;2) Shuxuetong Team: 20 cases, use Shuxuetong based on the treatment of LMWH Team.Comparison Team and Espial Team will respectively phlebotomize one time on 6:00 am at the 8th day prior and after treatment,5ml,separate blood serum and kept in referigratory of — 10V. determine chroma of ET and FBG in the same time.. Results:Before the treatment, the chroma of ET and FBG is evidently more height in Espial Team than Comparison Team. In thethird week after the treatment, the chroma of ET and FBG is evidently lower in Shuxuetong Team than LMWH Team(p< 0.05), cruor function is better in Shuxuetong Team than Comparison Team and LMWH Team, APTT and PT prolongs, but INR does not exceed 3(it is meet with the state standards, INR<3).Discussion:Vein endodermis covers all vein wall of body, it is the important parts of the body. Mr. Anderson's study proves vein endodermis cell is not only the selective barrier of the blood and the organic, but also the biggest internal, outer and self secretion metabolize organic, bringing and secreting several tens kinds of biology energid, controlling the shrink and open of vein, thrombosis, blood platelet activation and restraining. Mr. Gimbrone proves that the endodermis function barrier always accrues when the function changes or function lack of the above aspect, so it can result in the increase of vein wall tension, the exterior factor of block cracked, and the evidentchanges of cut power increase from the blood stream acting on vein block. It can be one of the recently prognostic indexes evaluating ACS.ET is polypeptides which is composed of 21 amino acid secreted by endodermis cell. Crinkle vein medium as far as possible, ET height of ACS patient, indirectly reflects abnormity height of ET of part Cyc. The chroma of inter coronary ET reaching some degree can result in vein convulsion, blood cream decrease, angina and acute cardiac muscle blood lock. Coronary is sensitive to ET. The animal experiment shows us that ET inducing coronary convulsion can result in cardiac muscle blood lock and lethality arrhythmia. Mr. Chester study shows that ET depends on the shrink effect of coronary and FBG is the most important gene of plasma viscosimet. Mr. Ernest believes that height chroma of blood fibre albumen can act VII gene, and act the organize enzyme acting enerfid stayer, which results in the blood viscous level increase, centralization of bloodplatelet better, the rate of artery thrombus increase. This changes of blood rheolgy can also evident affect on the cut speed of vein wall, so that it can accelerate the form of CAS damage and thrombosis, which aggravates endodermis function barrier. In this study, FBG is more height in ACS Team than Comparison Team. But Mr. Lindahl's study shows that FBGr maybe only some danger matter and its mechanism will not be clear, which is not worth forecasting the death of ACS patient in long-period and the short-period effect results from the form of thrombosis because of the evident height throma.Shuxuetong injection mainly composed of Hiruntin and Yin hormone. The effective study shows that blood stream changes is strong stimulation, Shuxuetong intervenes ET secretion, which maybe result from the Hiruntin and Yin hormone in Shuxuetong improving the blood stream changes of haggis heart patient, the fall of ET level shall regard with it. Otherwise, Hiruntin can also directive improve theendodermis function. The study clues on that Shuxuetong can bring CGRP, the heighten of CGRP benefit the contra-ET biology effect. Hirutin can form the introversion compounded matter together with thrombin, which acts on the compounded thrombin and has the effect. Modern medicine study considers earthworm can increase the melt active character of fibrinogen, reduce the fibrinogen in blood, reduce blood mucosity, restrain blood platelet to assemble and dissolve. The study shows that Hirutin can not result in the blood platelet reduce or the other cruor gene loss energy, it can be safe used.The value of this study is:1, The plasma levels of CRP and FBG in ACS group significantly elevated comparedwith the non-ACS;2, The plasma level of CRP in ACS group play an important role in the pathogenesis of ACS;3, Disuss the mechanism of the effective component Hiruntin of Shuxuetong improving the endodermis function, comparesShuxuetong with LMWH in some characters.