The Influence Of Modified Xiaoyao Powder In Leptin,Insulin Resistance Of The Non-alcoholic Pure Fatty Liver Of Liver Stagnation And Spleen Deficiency Type Patient

Objective:Probe to the probable function mechanism of Modified Xiaoyao Powder in the non-alcoholic pure fatty liver of Liver Stagnation and Spleen Deficiency Type patient;to observe the insulin resistance and the levels of serum leptin of the non-alcoholic pure fatty liver of Liver Stagnation and Spleen Deficiency Type patient;to investigate the effect of Modified Xiaoyao Powder in the non-alcoholic pure fatty liver of Liver Stagnation and Spleen Deficiency Type patient.Methods:1,Thirty healthy were selected as normal control group,sixty with non-alcoholic pure fatty liver of Liver Stagnation and Spleen Deficiency Type were divided into two groups at random:treatment group(Modified Xiaoyao Powder)and control group (general basic treatment),the time of treatment for eight weeks.2,Before and after the treatment of both treatment and control groups respectively test fasting serum leptin level,fasting serum glucose(FPG),insulin(FINS) level.3,Before and after the treatment of both treatment and control groups respectively compute and compare with the integral of symptom and physical signs and then assess effectiveness.Results:1,compared with normal control group,the levels of fasting serum leptin,the level of insulin(FINS),insulin resistance index were significantly statistics difference before treatment(P＜0.05).But to themselves,there were no statistics difference(P＞0.05).2,After treatment,a greatly decreasing in insulin resistance index had appeared in treatment group and control group(P＜0.05),however,the former lower than the latter(P＜0.05).3,After treatment,a greatly decreasing in fasting serum leptin level had appeared in treatment group and control group(P＜0.05),however,the former lower than the latter(P＜0.05).4,Their fasting serum insulin(FINS) level,insulin resistance index are positive correlated with fasting serum leptin level.5,After four weeks,the total effective rate of treatment group is percent60,the latter is percent56.7,By means of statistics analysis,there is no remarkable statistics difference between two groups(P＞0.05).6,After eight weeks,the total effective rate of treatment group is percent90,the latter is percent70,By means of statistics analysis,there is remarkable statistics difference between two groups(P＜0.05).Conclusions:Compared with normal control group,the level of fasting serum leptin, insulin resistance index were significantly statistics difference before treatment(P＜0.05);there is significant leptin resistance and insulin resistance in the non-alcoholic pure fatty liver of Liver Stagnation and Spleen Deficiency Type patient.Improving insulin resistance and leptin resistance may be the function mechanism of Modified Xiaoyao Powder in the non-alcoholic pure fatty liver of Liver Stagnation and Spleen Deficiency Type patient.Treatment group (Modified Xiaoyao Powder) is better than control group(general basic treatment) in improving the clinical symptoms;the effect of Modified Xiaoyao Powder in the non-alcoholic pure fatty of Liver Stagnation and Spleen Deficiency Type patient is obvious.