Expression Of ERK₂ And PI₃K Protein In Human Primary Hepatic Carcinoma Tissues

Objective:To evaluate the significance of extracellular signal regulated kinase 2(ERK₂) and phosphoinositide 3-kinase(PI₃K) protein expression in human primary hepatic carcinoma(PHC) tissues and the relationship between the expression and clinical pathological characterization.Methods:ERK₂,PI₃K protein expression in 50 cases of human primary hepatic carcinoma tissues,15 cases of non-cancer liver tissueswere detected by immunohistochemical method.Results:1.Both the positive rates of ERK₂ and PI₃K protein expression in malignant tumor were significantly higher than those in benign tissues.In human primary hepatic carcinoma and non-cancer liver tissue,ERK₂ positive expression rates were 54%and 20%(p＜0.05), PI₃K positive expression rates were 56%and 20%(p＜0.05).2.No significant correlation was found between the expression of both ERK₂, PI₃K pro-tein and the clinicopathological features of hepatocarcinoma. 3.There was a positive correlation between the expression of ERK₂ and PI₃K in well differentiation hepatocarcinoma.Conclusions:1.ERK₂ and PI₃K overexpression in PHC may play an important role in the carcinogenesis and progression 2.There may be a positive correlation between the expression of ERK₂ and PI₃K in well differentiation hepatocarcinoma.