The Clinical Study On Yikun Decoction To Kidney Yin Deficient Climacteric Syndrome Patient Serum 5-HT

Objective: Via clinical research, observing the clinical efficacy that women suffering from climacteric syndrome of deficiency of kidney-yin type are treated with Yikun Decoction and its impact on serum 5-HT levels in order to explore the serum 5-HT associated with the symptoms of hot flushes, sweating, dream of many sleepless nights, emotional symptoms such as restless and to investigate what the mechanism is.Methods: 64 cases of kidney-yin-deficiency-type climacteric syndrome have been treated by Yikun Decoction for 3 months. Improved domestic Kupperman score, the main symptoms of traditional Chinese medicine to improve the situation, serum sex hormone (E₂, FSH) and serum 5-HT, as observed for the self-control before and after treatment.Results:The clinical curative effect obviously rate reaches 81.25 % ;The peri-menopause group is 91.67%, and the menopause group is 67.86 %;the peri-menopause group curative effect is better than the menopause groups' (P<0.05) .Integral treatment of menopausal symptoms before and after there is significant difference (P<0.05) .Chinese medicine cardinal symptoms effectiveness in 65.0% above,hot flushes, sweating, loses sleep the total effectiveness respectively is 92.19%, 89.09 %, the mouth does the next best. After the treatment, the blood serum E₂ aggregate level elevates, but not remarkable difference. The peri-menopause group E₂ elevates, but the menopause groups' has not remarkable change. FSH drops, which has the statistical significance (P<0.05). 64 example patient's blood serum 5-HT level cures, the whole to have elevates; But non-statistics significance Before the treatment, the blood serum 5-HT level and E2, the FSH correlational dependence is not close; Assumes the relevance with the losing sleep degree, along with the losing sleep degree's aggravation, the blood serum 5-HT level assumes the declining trend; No significant relationship with hot flushes, sweating.Conclusion:Yikun Decoction is effective on treating climacteric syndrome of deficiency of kidney-yin type significantly, especially on improving the efficacy of hot flushes, sweating and insomnia ;And it is able to promote and adjusts the ovary which the function not yet completely declines secrete E2,suppresses the pituitary gland to press the gonadotrophic hormone the excessive secretion, adjusts the content of 5-HT.