The Volatile Oil Antipyretic Effects And Mechanism

LiguSticum chuanxiong Hort. is one of Chinese traditional trigs with thedrictions of Hoting flow of Qi and Blood and removing wind for stOPPing pain.In thes stUdy, it was fort obsmed tbat the essential oil of it could bring down thehigh temPerattire in labbit deduced by endotoxin. ms stUdy also, in level ofmolecule, probed into tlie mechedsm of this anipyTetic effect by first observing theessential oil's inIluence on the varying ofmonotalne ned transmitterResult shows that the anhpyTetic effect of the essential oil is proved byantipyredc exPeriment. The essential oil could brin down the temperatUr alongwith an increase of 5-hydroxy tryPttalne (5-HT) and dopamin (DA) and a decreaseof 5-hydroXy indo1e acetic acid(5-De) in hrpothaiamus in febrile rabbitS inducedby endotoxin. MeanWhile, the content of norePinePhrin NE) was not ialluenced.These suggeSt that the anndretic effeit of the essential oil of Ligushcumchuanxiong Hort. is relative to (changing the ratio of 5-hydroxy tryptamine (5-HT)and norepinephrine on) by increating the content of 5-hydroxy tryptaxnine (5-HT),xvhich finaIly influences the part of nervous system controlling temperatUre.