Clinical Study Of Therapeutic Effects By Different Comprehensive Interventional Treatments For Hepatocellular Carcinoma

Objective:To evaluate the clinical efficacy of transcatheter arterial chemoembolization(TACE), TACE combined with Epirubicin(EPI) and Lipiodol(LP), radiofrequency ablation(RFA) after TACE, and TACE combined with PEI in the comprehensive Interventional treatments of hepatocellular carcinoma(HCC). Use solid tumor effects WHO standards and the treatment criteria of comprehensive Interventional treatment to compare the therapeutic effects between different groups. Find the best therapeutic program for clinical use.Materials and Methods:Retrospectively analyzed the data of 113 patiens with primary HCC by treatment of four different comprehensive Interventional theraries from January 2006 to June 2007. They were divided into TACE group(48 cases), TACE+RFA group(23 cases), TACE+EPI+LP group(33 casese)and TACE+PEI group(9 cases).The therapeutic effects were then evaluated by the tumor shrinking rates observed from enhanced CT scaning afer one month and three months respectively, Each group after 2 months of alpha-fetoprotein (AFP) dropped 50% the proportion of,1-year and 2-year survival rates.Results:In the TACE+RFA group, the rates of tumor shrinking and the percentage of patients whose AFP levels reduced by half were higher than TACE group(P value were 0.005 and 0.007 respectively), The remaining two groups compared with the TACE group difference was not statistically significant.There were no statistically significant differences in terms of 1-year and 2-year survival rates between all groups.Conclusion:1. The therapeutic effects of four comprehensive Interventional treatments for hepatocellular carcinoma were definite.2. The combined therapy by TACE with RFA is more effective than the other three methods for the primary HCC, the differences were statistically significant.3. The combinative and sequential therapy of TACE and RFA mutually complementing, in coordination with each other , effective and safe. The combined therapy by TACE with RFA can significantly increase the quality of life of patients and reduce the relapse rate is the clinical than the ideal choice for a comprehensive intervention treatment. 4. The 1-year and 2-year survival rates were not statistically significant, it may be influenced by the small number of patients or the limited follow-up time. Further study will be needed.