The Effect Of Amlodipine On Lipid Modification Of Atorvastain

Hypertension complicated with coronary heart disease (CHD) is a serious threat to human health. Lipid modification is one of the most important measures in treatment of CHD. Amlodipine is not only a potent antihypertensive agent, but also has the effects of expanding coronary artery and anti-atherosclerosis, Therefore it is used widely in hypertensive patients complicated with CHD. Several international and domestic clinical studies suggested that amlodipine combined with atorvastain not only has an synergistic antihypertensive effect, but also can reduce the occurrence of cardiovascular events and improve long-term prognosis. In clincal practice, we also found that combination of these two drugs led to a pronounced improvement of lipid modification besides blood control. However, this findings have been reported rarely.Objective To observe the effect of amlodipine on lipid modification of atorvastain in hypertensive patients complicated with CHD.Methods 174 hypertensive patients complicated with CHD who had not taken lipid-lowering drugs for at least 4-6weeks were enrolled in this study and assigned to two groups:Group A were treated with amlodipine plus atorvastain, while group B with non-amlodipine based antihypertension plus atorvastain. Both groups received other conventional therapy of CHD, including aspirin. Plasma lipid profile, hepatic enzymes, creatine kinase and adverse events were assessed at baseline and week 2,4, and 8 after treatment.Results There was no significant difference between the two groups in the baseline clinical characteristics, such as plasma total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol (HDL-C) levels (P＞0.05). In contrast to the levels before treatment, TC and LDL-C in both groups decreased significantly at week 2,4, and 8 (P＜0.05). In group A, HDL-C was elevated at week 4 and 8, while TG declined significantly after 8 weeks' administration (P＜0.05). In group B, HDL-C tended to be higher and TG appeared to be lower than those before treatment, but the difference did not reach statistical significance (P＞0.05). In comparison with group B, the levels of TC and LDL-C in group A declined significantly after treatment of 4 and 8 weeks, and HDL-C increased notably after 8-week treatment (P＜0.05).Conclusions amlodipine may promote the effect of atorvastain in regulating lipid profile, and there were no obvious adverse events in the combination treatment with such two classes of drugs.