A Study Of The Relationship Between Complement C5a And UAER In Type 2 Diabetes Mellitus

Objective To investigate the relationship between complement C5a and diabetic nephropathy.Methods The concentrations of plasma C5a and urine C5a was examined in 39 patients with type 2 diabetes mellitus,21 healthy volunteers served as controls.The relationship between complement C5a and UAER was analyzed.Resuts Compared with healthy controls,urine level of C5a was increased in the diabetic nephropathy group(11.44±21.17 vs 76.38±144.48,P=0.046),which was positively correlated with UAER.The diabetic course and urine C5a are the independent predictors of urine albumin excretion rate(r=0.378,P=0.023)Conclusion The activation of complements might involve in the pathogenesis of diabetic renal complication.