| Varicocele (Varicocele, VC) is a common disease among men, means spermatic vein blood flow due to siltation caused by spermatic venous plexus racemosum expansion, tortuous, and variable length. The disease incidence in the general male population of about 2%-22.6%, while in infertility patients about 5.7%-41% have different degrees of varicocele, more common in young adults. According to WHO regulations, when couples living together for more than a year did not take any contraceptive measures, we named male infertility as the man who causes female infertility. VC cause of infertility is the result of several factors together, its mechanism is currently not entirely clear:scrotal temperature rise, reactive oxygen species damage, effect of NO and so has long been considered to be an important factor leading to infertility, this view has been gradually for domestic and foreign scholars recognized, but the influence between the time of varicocele and the male infertility still exits some disputes. In this paper, from April 2004 to October 2009 in due to infertility to hospitals in Jilin University VC of the 30 cases of patients with test results of semen analysis. Comparison of patients with varicocele of different periods of the changes in semen parameters between patients to understand the course of the development of varicocele patients fertility effects. Purpose:Varicocele ofter cause infertility, the study of varicocele treatment in infertile men have an important significance. This paper is to study the the relationship between prevalence of varicocele time and semen parameters, for better understanding of the occurrence and development of varicocele on fertility in order to facilitate better diagnosis and treatment of the disease. More over the ability to improve fertility.Methods:We choice the patients who has the varicocele in infertile 30 cases, aged 21-42 years (mean 32.33 years), their spouses had pregnancy history, semen parameters may be that its a good risk of infertility before the non-VC history, married 1-12 years (mean 3.71 years) of infertility, excluding external genitalia, testicular congenital anomalies or history of trauma, urinary and reproductive tract infection, sexual dysfunction, infertility, and other spouse does not affect fertility diseases. All patients were examed by a good doctor who has clinical experience for many years, according to commonly used clinical method to search the body of varicocele patients with sub-degree, this article will be duration of VC<3-year patient as the A group (n= 14, an average of 1.38 years), the patients with duration of VC≥3 years as the B group (n= 16, mean 5.75 years). Applications SPSS 16.0 package for data processing, in which A varicocele group and B group of all data on the relationship between applications independent samples t test, test data with (?)±s, A value of P＜0.05 was considered to be statistically significant.Results:In contrast to VC two groups of patients with semen parameters, A group sperm density (79.26±33.61×106/ml), sperm motility (32.25±11.46%),sperm motility (44.19±14.43%) and sperm morphology analysis of the results were better than the B group, semen parameters (respectively,33.61±33.05×106/ml,17.98±11.36%,24.93±15.28%). Semen quality, sperm count and normal morphology, small and amorphous head sperm was considered to be statistically significant. (P＜0.05).Conclusion:In this study appear in the A group (mean disease duration of 1.38 years) patients, sperm motility as a sensitive indicator of spermatogenic function with standard sperm motility (≥50%) decreased significantly compared with the duration of VC, B group (average disease duration of 5.75 years) in sperm motility has reached severe oligozoospermia, between the two groups was statistically significant (P＜0.05). The morphological analysis of sperm damaged as a sensitive indicator,the two groups in this paper the normal form of sperm were significantly decreased, and the B group of normal sperm morphology is close to half of the standard. In the abnormal sperm, the two groups of patients with small-head sperm and amorphous head sperm have suffered significant difference. In other sperm morphology were not apparent in the differences. The above figures reveal that with time, a significant decline in semen parameters seriously affect the patient's reproductive capacity, this article from the spermatic vein blood flow changes and molecular perspective of the sick time on the VC in patients with serious implications, so we considered infertile should be taken observation if it is found to be VC in patients and give early treatment, which is to restore fertility and increase pregnancy rates have important significance.
|
PDF Full Text Request