Studies On Gels Of Venenum Bufonis

The prevalence rates of oral ulcer is high, the recurrence rates of oral ulcer is high, and oral ulcer is hard to cure as a kind of common disease. The prevalence rates of oral ulceration increases sharply as modern life pressure increasing and the pollution of environment getting severely. It takes a long time to cure this disease and it is difficult to heal with a high recurrence rates, although the symptoms of oral ulcer is not very serious. The symptoms of oral ulcer have a bad influence on the quality of sufferer 's life.Venenum Bufonis gels is a kind of new drug of treating oral ulcer according with the study of pathology, etiology and clinical symptom of oral ulcer. Venenum Bufonis gels is also combined with the theory of Chinese Traditional Medicine. The clinical results of the gels is safe, convenient and effective. The main ingredients of Venenum Bufonis gels is a kind of compounds with smaller polarity in Venenum Bufonis.Venenum Bufonis is our valuable Chinese Herbal Medicine. It tastes bitter and spicy. Modern medical research shows that Venenum Bufonis can elevate blood pressure, increase heart rate, anti-cancer, resist fatigue, anti-inflammatory, enhance immunity, has the efficacy of local anesthesia and analgesia etc. In a word, Venenum Bufonis has various pharmacological activities and has a great of value to develop and applicant. Gels is a half solid preparation which has a simple preparation method. It is easy to pack, storage and transport. The research of gels of Traditional Chinese Medicine has a great of economic and social benefits combined with dialectical theory of Traditional Chinese Medicine and modern research methods.This paper mainly studies the technological process, prescription, character, quality standards, preliminary stable research and acute toxicology reaesrch of Venenum Bufonis gels. It also studies the main existing problems at present. In the end, this paper excogitates a safe, reliable, simple and reasonable method of preparation and establishs quality standards finally. This paper provides credible theoretical foundation for taking medicine safely, reasonablely and effectively. This thesis mainly includes:(1)This paper extracts the major components of Venenum Bufonis. TLC method is used in the qualitative identification of resibufogenin and cinbufagin. High performance liquid chromatography method is used to study the determination of major components of Venenum Bufonis. This paper developes a preparation of lowest concentration limit of resibufogenin and cinbufagin at last.(2)The thesis systematically studies the gels of HPMC, carbomer, PVA, CMC-Na, gelatine and organogel of lecithin, tween, span, poloxamer, isopropyl myristate. This paper selectes HPMC as matrix of Venenum Bufonis gels ultimately and determines the prescription of the gels.(3)The paper discloses the process for preparing the medicament through a large number of experiments.(4)The paper studys the properties, pH, viscosity, miscrostructure, the amount of skinpermeation, preliminary acute toxicological studies. Also it establishes the determin-ation method of Venenum Bufonis gels and builds the general investigation methods of stability of the gels.