Clinical Observation On Deep Venous Thrombosis Influence After Major Surgery Orthopedics With The Tablet Of Huo Xue Ling

Objective:Observating the variation of hemorheology and prothrombin time and activated partial thromboplatin time after major surgery orthopedics with the tablet of Huo Xue Ling. Hope for the tablet of Huo Xue Ling has the functions of promoting blood circulation and reducing high blood coagulation, and high-viscosity through the forthebetter of these indexes. Decreasing the risk factors of deep venous thrombosis after major surgery orthopedics, consequently decreasing the rate of deep venous thrombosis.Method:90 patients with major surgery orthopedics(Including prosthetic replacement for femoral head, total hip arthroplasty, fixation around the line of hip fracture and total knee arthroplasty)were selected from Dongguan Hospital of TCM during November 2008 to February 2010, and were divided into three groups at stratified randomization. Three groups were given The tablet of Huo Xue Ling, Low molecular weight heparin and The tablet of Huo Xue Ling, Low molecular weight heparin, were using to 10 days. Compared the variation of hemorheology and prothrombin time and activated partial thromboplatin time when preoperatively, after the first and 14th day of the operation. Compared the deep venous thrombosis rate of them.Results:1. HemorheologyThe results showed that the hemorheology of these three groups had no significant difference(P>0.05)before treatment. The erythrocyte sedimentation rate of these three groups themselves had significant difference (P<0.05) between before treatment and the first day of the operation. Although the rest of hemorheology had no significant difference(P>0.05), However, The average of hemorheology after operation was lower than before treatment. The whole blood viscosity, The high-shear relative index of whole blood, The low-shear relative index of whole blood,The low-shear reduced viscosity of whole blood and The high-shear reduced viscosity of whole blood reduced when after the 14th day of the operation, showed significant difference (p<0.05). The hemorheology of group B was better than group A and C when after the 14th day of the operation. Most of hemorheology had no significant difference (P>0.05) between group A and group C. But the Plasma viscosity of group C and group B was better than group A showed significant difference(p<0.05).2. Coagulation group seized IndexThe results showed that the prothrombin time and activated partial thromboplatin time of these three groups had no significant difference(P>0.05)before treatment. The prothrombin time of these three groups themselves had significant difference(P<0.05)between before treatment and the first day of the operation. But comparing the activated partial thromboplatin time had no significant difference(P>0.05). The prothrombin time and activated partial thromboplatin time of these three groups themselves had significant difference(p<0.05)between before treatment and the 14th day of the operation. The prothrombin time of the group A had significant difference (p<0.05) among group B and group C when after the 14th day of the operation, But the activated partial thromboplatin time had no significant difference(P>0.05).3. Deep venous thrombosis rateThe results showed that Ninety cases, a total of eight cases occurred DVT, with a total incidence of 8.89 percent, in which group B occurred two cases of DVT rate of 6.67 percent, group A and group C all occurred three cases of DVT rate of 10.00 percent.Conclusion:Most of hemorheology significantly reduced after using the tablet of Huo Xue Ling or Low molecular weight heparin, Huo Xue Ling was worse than Low molecular weight heparin to reducing in plasma viscosity. The prothrombin time and activated partial thromboplatin time were significantly extended after using the tablet of Huo Xue Ling or Low molecular weight heparin, but the Low molecular weight heparin was better than Huo Xue Ling. The Hemorheology of patients can be reduced and the Coagulation group seized Index of patients can be extended and the high blood coagulation, and high-viscosity of patients can be improved after major surgery orthopedics with the tablet of Huo Xue Ling. The effect is better when using the tablet of Huo Xue Ling and Low molecular weight heparin at the same time. So we can prevent the formation of DVT after major surgery orthopedics combining treatment of traditional Chinese medicine and western medicine in clinically.