Study Of The Relationship Among Ankle-Brachial Index For Extracranial And Intracranial Arterial Stenosis

Objective:To investigate the relationship among ankle-brachial index(ABI)and risk factors of ischemic stroke and intracranial and extracranial arterial stenosis,and to evaluate the relationship among ABI and the extent and sites of intracrania arterial stenosis and the number of relevance to guide clinical prevention.Methods:To collect 104 patients with ischemic stroke patients during from July in 2008 to December in 2009 at the First Affiliated Hospital of Chifeng College, all patients underwent CT angiography (CTA) or magnetic resonance angiography (MRA), carotid artery color Doppler ultrasound (CDUS), Transcranial Doppler (TCD) to determine whether there is intracranial arterial stenosis or Extracranial artery stenosis.Extracranial artery stenosis according to North American symptomatic carotid artery stenosis testing method (NASCET) were divided into four groups:normal, mild stenosis, moderate stenosis, severe stenosis.Intracranial arterial stenosis according to TCD peak systolic flow velocity divided into four groups:normal,mild stenosis,moderate stenosis, severe stenosis.The number of branch of patients with stenosis were divided into non-restenosis group, one vessel stenosis group, two artery stenosis group, three or more vascular stenosis. Risk factors were recorded such as age,gender, history of diabetes,hematological indicators of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and measure height, weight, calculate body mass index (BMI) and ankle-brachial index (ABI). Results:1. It was no statistical difference between Electronic Blood Pressure Monitor and mercury sphygmomanometer.ABI was no statistical difference between Electronic blood pressure monitors and Doppler ultrasound measurements.2.The incidence of intracranial arterial stenosis (45.18%) is greater than the incidence of extracranial arterial stenosis (23.08%).3.It was no statistical difference between intracranial arterial stenosis and ABI.4.It was statistical difference (P= 0.003<0.05)between extracranial artery stenosis and ABI.It was statistical difference(P<0.05) between severe stenosis and other groups.5.ABI was statistical difference (P= 0.003<0.05)between the normal group and other vascular stenosises, ABI of blood vessels narrow is less than the normal group. However, there was no significant difference between normal group and one, and two lesions, but in three or more lesions group with other vascular stenosises, there are statistically significant(P<0.05).6. Receiver operating characteristic (ROC) curve was drawn about the predictive value of ABI on three or more lesions. the area under ROC curve was 0.78.6±0.078(95% CI 0.72～0.86, P<0.001), ABI≤0.9 has a high specificity, relatively good sensitivity and accuracy as the prediction of three or more lesions of intracranialand extracranial arterial stenosis.Conclusion:1. Electronic blood pressure monitor can be used as a way to check the ABI.2. The incidence of intracranial arterial stenosis is greater than the incidence of extracranial arterial stenosis.3.ABI has nothing to do with intracranial arterial stenosis, and related severe extracranial artery stenosis, and related lesions count. ABI to three or more lesions has the high prospective value.