TCM Syndrome Differentiation Of Depression Patients In S-ET Analysis

ObjectiveSET (SuPPer EEG Technology) system is used to brain function tests. Patients with depr-ession are used to test and neurotransmitters such as 5-HT, acetylcholine, dopamine, norepinephrine, depression neurotransmitters(γ-aminobutyric acid, glycine, etc.), excited neurotransmitters (glutamate, etc)are examined. Neurotransmitters in depression patients and normal subjects are examined and compared, Traditional Chinese Medicine (TCM) types and its correlation were compared. This study is to identify the differences of S-ET between patients and normal people, to identify the differences of S-ET between different TCM types and normal people, to identify the differences of S-ET between different TCM types. Also this study tested the balance between DA and 5-HT, ACH and NE. Wish to provide an objective reference for the diagnosis of depression and treatment determination based on TCM Syndrome differentiation, TCM theory can be used to explain mechanism of depression.MethodCollect the 244 depression patients totally. There are 71 ordinary person in compari-son group. Measure the depression patients and the normal person's S-ET, deal with the data by SPSS 13.0 statistics software.Result:1. Contrast with the normal man, depression patient's 5-HT(P<0.01), ACH (P<0.05), DA (P<0.01), NE(P<0.01), EXC(P<0.01) brain function distinct fall. 2. Contrast S-ET with the normal man and five TCM syndrome types, depression patient's lower brain function than normal man's S-ET:Liver qi stagnation:5-HT (P<0.05),ACH (P<0.01),DA (P<0.05),NE (P<0.01),EXC (P<0.05) brain function distinct fall. (ACH76%, NE74%)Liver stagnation and spleen deficiencies:5-HT (P<0.05),DA (P<0.01),NE (P<0.05) brain function distinct fall. (DA 70.21%,5-HT 61.7%)Liver stagnation and phlegm obstruction:5-HT (P<0.01),DA (P<0.01),NE (P<0.05), EXC (P<0.05) brain function distinct fall. (DA 81.13%,5-HT 75.47%)Deficiencies of both the heart and spleen:DA (P<0.05),EXC (P<0.05) brain function distinct fall. (DA 75.61%, EXC 63.41%)Non-interaction of heart and kidney:5-HT (P<0.05),DA (P<0.05) brain function distinct fall. (5-HT 62.26%, DA 62.26%)3. Contrast S-ET with the normal man and five TCM syndrome types, depression patient's hyper brain function than normal S-ET:Liver qi stagnation:S-ET hyper-function rates:5-HT 44%, ACH 24%, DA 34%NE 26%EXC 36%, (5-HT 44%, EXC 36%)Liver stagnation and spleen deficiencies:S-ET hyper-function rates 5-HT 38.3%,DA 29.79%,NE 40.43%. (NE 40.43%5-HT 38.3%)Liver stagnation and phlegm obstruction:S-ET hyper-function rates:5-HT 24.53%, DA 18.87%, NE 32.08%, EXC 32.08%(INH 67.92%, NE and EXC 32.08%)Deficiencies of both the heart and spleen:DA 24.39%, EXC 36.59%Non-interaction of heart and kidney:5-HT 37.74%, DA37.74%.4. Contrast S-ET between TCM syndrome typesLiver qi stagnation ACH brain function (0.01±11.53) distinct fall with Deficiencies of both the heart and spleen (7.22±11.36) (P<0.01) and Non- interaction of heart and kidney (5.16±11.49) (P<0.05).5.5-HT and DA, ACH and NE all have positive correlation(P<0.01). Contrast with the normal man, depression patient's the subtrahend value of 5-HT and DA i s distinct fall(P<0.01); depression patient's the subtrahend value of ACH and NE is distinct fall(P<0.05).Conclusions:1.Depression patients with normal man's brain function show different in SET. Contrast with the normal man, depression patient's 5-HT, ACH, DA, NE, EXC brain function distinct fall. Pathogenesis of depression could be correlative to the lower function of neurotransmitter. Through the study found, depression patients also have Hyper-function with Neurotransmitter. We can infer that depression is not be decline or be enhanced with all neurotransmitter function.2. Five TCM syndrome types and depression patient's S-ET are different.3. Between Five TCM syndrome types also have difference function in S-ET.4. between 5-HT and DA, ACH and NE have The relationship of antagonism, contrast depression patient with the normal man, the subtrahend value in 5-HT and DA, ACH and NE show distinct fall, Speculated that neurotransmitter imbalance is related to depression.