The Role Of Different Subtypes Of CD4~+T Lymphocyte In IFN-α Therapy For Hepatitis B

[Objective] To study on the role of different subtypes of CD4+ T lymphocyte in IFN-αtherapy for hepatitis B.[Methods] Th17,Th1,Th2 type cytokines were assayed by enzyme-linked immunosorbent assay(ELISA) in 54 hepatitis B patients before and 24 weeks after their IFN-αtreatment. Patients were grouped based on responses to IFN-αtherapy. The data were analyzed with t-test and Pearson correlation analysis.[Results] The level of IL-17 was slightly lower at 24 weeks following IFN-αtreatment than that of pre-treatment(P>0.05), and the level of IFN-y was slightly higher(P>0.05), and the level of IL-4 was substantially lower than that of pre-treatment(P<0.01). In patients with a complete response to IFN-α, the level of IFN-γwas obviously increased (P< 0.01), but the levels of IL-17 and IL-4 were significantly decreased (P<0.05,<0.01).[Conclusion] During IFN-αtherapy, the function of Th17 and Th2 are down and the function of Th1 up in chronic hepatitis B.And the more their function change the better result we can get.