Correlation Study Of Metabolic Syndrome And Benign Prostatic Hyperplasia

PartⅠCorrelation study of metabolic syndrome and prostate volumeObjective:To explore the relationship between metabolic syndrome (MS) and its components and prostate volume,and to clear out possible factors related to BPH etiology.Methods:One thousand and ninety-eight males aged 36-90 years were divided into two groups according to the definition of MS by CDS in 2004:MS group and control group. They were sampled randomly from the population who did healthy body examination in Shandong Provincial Hospital Health Examination Center. All of the subjects were Chinese Han males,and patients with diagnosis of prostate cancer, medical treatment for BPH and a previous history of prostate or urethral surgery were excluded from the study. MS group were composed of 218 cases, aged 38 to 90 years old, and the average age was 58.1±11.6 years, while there were 880 cases in control group, which aged 36 to 90 years old, and the average age was 58.0±12.5 years. The blood pressure,body weight and height were measured, and the body mass index (BMI) was calculated. Serum fasting blood glucose (FPG),total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were measured using an autoanalyzer. Prostate specific antigen (PSA) was measured by radionimmunoassay (RIA). Prostate volume was measured by abdominal ultrasound. All statistical tests were carried out using the SPSS 13.0-program. Measurement data interclass was indicated withχ±s.The count data was expressed by cases and percentage. The comparison between groups were tested using t test. The frequencies between the cases and controls were tested usingχ2-test. Samples of different age groups were compared with single-factor analysis of variance, and variables in MS groups were analyzed by Pearson correlation analysis.Results:1. In the first group with metabolic syndrome,98 (45.0%) had diabetes mellitus, 172 (78.9%) had hypertension,204 (93.6%) had obesity,174 (79.8%) had hypertriglyceridemia,46(21.1%) had a serum HDL-C level<0.9mmol/L., 208 (95.4%) had the enlargement of prostate volume (>20ml)。In contrast, in the control group,45 (5.1%) had diabetes mellitus,204 (23.2%) had hypertension,469(53.3%) had obesity,218(24.8%)had hypertriglyceridemia, 32 (3.6%) had a serum HDL-C level<0.9mmol/L,770 (87.5%) had the enlargement of prostate volume (>20ml).2. The BMI, systolic blood pressure, diastolic blood pressure,fasting plasma glucose, serum triglyceride, total cholesterol, prostate volume and PSA levels were higher, while serum HDL-C level was lower in MS group than in control group, and they had significant difference (all P<0.05). While the serum LDL-C level between MS group and control group had no significant difference (P> 0.05).3. The prostate volume was positively correlated with serum PSA level (r=0.350, P<0.01),age (r=0.429, P<0.01),BMI (r=0.145, P<0.01) and systolic blood pressure (r=0.133, P<0.05),and was negatively correlated with diastolic blood pressure (r=-0.193, P<0.01)4. The serum PSA level was positively correlated with age r=0.310, P<0.01), triglyceride (r=0.162, P<0.05), and systolic blood pressure (r=0.157, P<0.05),while had no correlation with diastolic blood pressure or BMI.5. Compared with control group, the prostate volume was enlarged in MS group [(37.8±21.3) ml vs. (31.0±11.1) ml, P<0.01]. The incidence of the enlargement of prostate volume (>20ml) in MS group was higher than that in the control group[were respectively208 (95.4%) and 770 (87.5%)], and there was significant difference (χ2=11.2379, P<0.01).6. The prostate volume and serum PSA level in MS group increased with ages,but between the group aged 36-50 and 50-59 years, there was no significant difference (P>0.05).While between the group aged 50～59 and 60～69 years, there were significant differences (P<0.05). Between the group aged 70～90 and other three groups, there were significant differences (P<0.01).Conclusion:Metabolic syndrome is related to the enlargement of prostate volume.And it may be one of the risk factors in the processes of BPH occurrence and clinical progression.PartⅡAssociation study between type 2 diabetes mellitus and benign prostatic hyperplasiaObjective:To assess whether type 2 diabetes mellitus affects the occurrence and progression of benign prostatic hyperplasia.Methods:177 males with type 2 diabetes mellitus were selected according to WHO 1999 diabetic criteria, and 225 age-matched males as normal control group were enrolled in this study. They were all sampled randomly from the population who did healthy body examination in Shandong Provincial Hospital Health Examination Center.The blood pressure,body weight and height were measured, and the body mass index (BMI) was calculated. Serum fasting blood glucose (FPG),total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were measured using an autoanalyzer. Prostate specific antigen (PSA) was measured by radionimmunoassay (RIA). Prostate volume was measured by abdominal ultrasound. All statistical tests were carried out using the SPSS 13.0-program. Measurement data interclass was indicated withχ±s.The count data was expressed by cases and percentage. The comparison between groups were tested using t test. The frequencies between the cases and controls were tested usingχ2-test, and variables in T2DM group were analyzed by Pearson correlation analysis.Results:1. The comparison of clinical and biochemical characteristics between type 2 diabetes mellitus group and control group:The BMI, systolic blood pressure, fasting plasma glucose, serum triglyceride, total cholesterol, serum LDL-C, prostate volume and PSA levels were higher,while the serum HDL-C level was lower in type 2 diabetes mellitus group than in control group, and they had significant difference (all P<0.01). While the diastolic blood pressure between the two groups had no significant difference (P>0.05).2. In type 2 diabetes mellitus group, the prostate volume was positively correlated with the fasting plasma glucose (r=0.189,P=0.012) and serum PSA level (r=0.270, P=0.000), and was negatively correlated with diastolic blood pressure (r=-0.151,p=0.044), total cholesterol (r=-0.186,P=0.013),LDL-C (r=-0.208, P=0.006).While the prostate volume had no correlation with age, BMI, SBP, TG, HDL-C.3.In type 2 diabetes mellitus group, the serum PSA level was positively correlated with prostate volume(r=0.270, P=0.000), age(r=0.272,P=0.000), systolic blood pressure (r=0.188, P=0.012) and total cholesterol (r=0.176, P=0.019),while had no correlation with diastolic blood pressure, BMI, serum triglyceride, serum HDL-C,serum LDL-C or fasting plasma glucose.4.The incidence of BPH in type 2 diabetes mellitus group and control group: Tested byχ2-test, the incidence of BPH in type 2 diabetes mellitus group was obviously higher than it in control group,and there was significantly difference (x2=10.53,P<0.001).Conclusion:Type 2 diabetes mellitus could be one of the risk factors in the process of BPH growth and progression.