A Case Control Study: The Correlation Between Cholecystectomy, Cholecystolithiasis And Colorectal Carcinoma

Objective:To investitate the correlation between cholecystectomy, cholecystolithiasis and colorectal carcinoma.Methods:Compair the percentage of 436 colorectal carcinoma patients as test group with 491 gastric cancer patients as control group.All cases in both groups were admitted into Qilu hospital affiliated to Shandong university college of medicine during Jan.2003 to Dec.2009.Calculate the patients with cholecystectomy, cholecystolithiasis,make a X2 test statistical analysis with the sex factor as subgroup factor.Results:All 927 patient cases were collcted during Jan.2003 to Dec.2009 in Qilu hospital affiliated to Shandong university.all cases have pathologic diagnosis. 426 patients suffered colorectal carcinoma(male:229,female:207),from 28 to 76 years old,at an average age of 58.7 years old.In these patients,33 of them have a history of cholecystectomy(male:16,female:17),and 62 of them have a history of cholecystolithiasis or a diagnosis of cholecystolithiasis since in patient (male:18,female:44).491 patients sufferred gastric cancer(male:231,female:260),from 25to 72 years old,at an average age of 56.4 years old. In these patients,34of them have a history of cholecystectomy(male:16,female:18),and 45 of them have a history of cholecystolithiasis or a diagnosis of cholecystolithiasis since in patient (male:21,female:24). All the data were used for X2 test with statistical software SPSS16.0. A 2x3 table X2 test showed that there is a significant disparation in the percertage of cholecystectomy cholecystolithiasis between the test group and the control group(X2=6.169; P=0.046<0.05).sexual subgroup analysis showed no disparation in male(X2=0.225; P=0.894>0.05),but significant disparation in female(X2=14.322;P=0.001<0.05).This sugested that cholecystectomy and cholecystolithiasis could be risk factor for colorectal carcinoma in female more than in male.The 2x2 table X2 test for cholecystectomy subgroup showed no significant disparation between the test group and the control group(X2=0.150;P=0.698> 0. 05,OR=1.103,95%CI 0.670～1.814),and sexual subgroup test showed no disparation,either (male X2=0.001,P=0.980>0.05,OR=1.009,95%CI 0.670～1.814; female X2=0.276,P=0.599> 0.05,OR=1.103,95%CI 0.492-2.070). The 2x2 table X2 test for cholecystolithiasis subgroup showed that there is a significant disparation in the percertage of cholecystolithiasis between the test group and the control group(X2=5.78,=0.016<0.05, OR=1.643,95%CI 1.093-2.470).Sexual subgroup test showed no percentage disparation in male(X2=3.571,P=0.059> 0. 05,OR=0.980,95%CI 0.510～1.895),but significant disparation in female(X2 =13.996,P<0.0001<0.05 OR=2.654,95%CI 1.553～4.536).This suggested that women with cholecystolithiasis seem to have higher risk to suffer colorectal cancinoma.Conclusions:The results of X2 test analysis show that cholecystectomy has nothing to do with colorectal carcinoma,but women with cholecystolithiasis seem to have higher risk to suffer colorectal cancinoma.