Expression And Significance Of C-myc, FBP1 And FIR In Human Bladder Urothelial Carcinoma

ObjectivesTo investigate the expression of c-myc, FBP1 and FIR in hunman bladder urothelial carcinoma tissues and further to explore the correlation between their expression and the tumor grade and clinical stage.MethodsImmunohistochemical SABC method was used in detecting the expression of c-myc, FBP1 and FIR in 53 cases of bladder urothelial carcinoma and 15 cases pericancerous normal bladder tissues. Computer image analysis and manual counting are used to estimate the immunohistochemistry results, and the statistic software was used to analyze the correlated information.ResultsThe expression rate of c-myc, FBP1 and FIR in bladder urothelial carcinoma was 60.4%,81.1% and 52.8%, respectively, and there were significant differences compared with that in the pericancerous normal bladder tissue. The expression of FBP1 was positively correlated with tumor grade and the expression of FIR was positively correlated with tumor grade and clinical stage. The expression of c-myc was positively correlated with the expression of FIR.ConclusionsThe overexpression of c-myc, FBP1 and FIR might play significant role in carcinogenesis, invasion, infiltration and metastasis, and might be helpful in the diagnosis and therapy of bladder urothelial carcinoma.