Insulin Resistance And B Cell Function After Delivery In The Gestational Diabetes Mellitus

PurposeTo investigate insulin resistance and B cell function after delivery in the gestational diabetes mellitus (GDM).MethodsAccording to oral glucose tolerance test (OGTT),8 women with a history of gestational diabetes mellitus(GDM) who have normal glucose tolerance is NGT group.Compared with 8 women with a history of GDM who have impaired glucose tolerance as IGT group. Insulin resistance was measured using hyperinsulin-euglycemic clamp, and B-cell function was assessed by intravenous glucose tolerance test (IVGTT).ResultsBMI and triglyceride in NGT group and IGT group are alike level; The glucose injection rate of IGT group is smaller than that in NGT group(5.70±1.14 VS 7.79±1.75, P<0.05); The first phase insulin secretion of NGT group is higher than that of IGT group(5.32±0.37 VS 4.35±0.46, P＜0.05); There is no difference between the IGT group and the NGT group(4.35±0.31 VS 4.38±0.56, P>0.05).ConclusionsThere is more insulin resistance and more B cell function impairment in women with a history of GDM who have impaired glucose tolerance than that who have normal glucose tolerance.