Efficacy Analysis Of PTU Plus Triamcinolone In Treatment Of Hyperthyroidism Caused By Autoimmune Thyroid Disease

ObjectivesTo observe the therapeutic effect of PTU plus triamcinolone in treatment of hyperthyroidism caused by autoimmune thyroid disease (AITD).MethodTotally 60 patients with hyperthyroidism caused by AITD were randomized into 2 groups:PTU treatment group (group A) and PTU combined with triamcinolone treatment group (group B). The two groups were measured by serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin antibody (TGAb) and thyroid peroxide antibody (TPOAb) before and 4 months after treatment. Group B was also measured cortisol, adrenocorticotropic hormone (ACTH), plasma glucose.ResultsAfter 4 months treatment, the levels of serum FT3, FT4, TSH were improved in both groups, but the levels of TSH of group B were improved more evidently. The levels of TGAb and TPOAb in group A had no significant change. But compared with the group A, the levels of TGAb, TPOAb and the average level of PTU in group B were lower(P<0.05).ConclusionsThe therapy of PTU plus oral triamcinolone can significantly decrease the levels of serum TGAb and TPOAb, and recover thyroid function faster.