The Research Aboat Effect Of Qiangji Jianli Fang And Effective Component On Preventing And Treating The Spleen Deficiency Syndrome

ObjectiveChoose one components of proprietary QiangJiJianLi. Copy pixu animal models, research on two kinds of effective constituents polysaccharides a nd total bge from drug HuangQi in the spleen deficiency in rats. Then stud y the influence of the immune system and components of the two kinds of e ffective mechanism is discussed, and further explore the proprietary of t he spleen deficiency, and mechanism. In order to provide the basis for th e next research and Clinical applicationMethod1. TheoryFor proprietary QiangJiJianLi, astragalus membranaceus polysaccharide, astragalus membranaceus total glycosides and spleen deficiency from the four aspects of the theory and experiment are reviewed in this paper, com bined with the topic of past research results, using open square, using t he method of study of astragalus gentleman medicine group is divided into two kinds of effective, choose repeatability, relatively high specificit y of cytokines, thyroid hormones, hormones, amylase, albumin at the exper iment.2. Experimental studySelecting health SD rats, rhubarb copy of pixu animal models with dru g DaHung, at the same time serve the rhubarb filling with drug prevention, for 15 days, proprietary QiangJiJianLi group, astragalus total polysacchar ide group, astragalus membranaceus group, Qiangji astragalus total polysa ccharide group, Qiangji astragalus membranaceus group. The gentleman medic ine will total polysaccharide and astragalus nucleoside and separate, obs erve party group rats generally, thyroid hormones, hormones, cytokines, r ing nucleotide, amylase, albumin, through the comparison of the drug effi cacy, study the mechanism of proprietary QiangJiJianLi and the use of ast ragalus in total polysaccharide and astragalus nucleoside in the propriet ary.ResultGenerally, the animal model of pixu rhubarb from the fourth day bega n to weight loss, narrowed eyes, lazy, gathers, timidity, then strip body hair loose stools, wait for a symptom, and with the extension of time sy mptoms gradually increase. The clinical manifestations of patients with s pleen is very similar. Compared with the normal control group, spleen mod el rats, significant weight loss (P<0.01), the treatment group can preven t rats were falling weight, statistical significance.Thyroid hormone:compared with the normal control group, spleen model rats T3, and T4 concentration (P<0.01) rT3 content increased (P<0.05), TSH levels without feedback. Compared with the spleen, Qiangji group, nutril ite force of astragalus polysaccharide can make T3, T4 content increased s ignificantly (P<0.01) rT3 levels drop (P<0.01), astragalus membranaceus to tal content of mangiferin group can make T3, rT3 content increased and T4 c ontent influence declined slightly, but this was not statistically signif icant.Hormone:Compared with the normal control group, spleen model, serum E2 elevated levels (P<0.05-0.01), E2/T ratio increased (P<0.05). Qiangjiji anli group can significantly increased E2 content (P<0.01), improve T cont ent(P<0.05), E2/T drop ratio, Astragalus polysaccharide, Qiangji group tot al polysaccharide, astragalus membranaceus, Qiangji nucleoside group tota 1 content of mangiferin group E2 to have the varying degree of lower (P<0. 01), astragalus membranaceus, Qiangji total nucleoside total content of m angiferin T drop group(P<0.05), and the four groups can be different degr ees E2/T ratio, but this was not statistically significant.Cytokines:spleen model rats TNF, IL-2, IL-6 levels than normal contr ols were decreased significantly (P<0.05-0.01), Qiangjijianli group and a stragalus polysaccharide, astragalus can obviously increase total nucleos ide group serum TNF content (P<0.01), Qiangji groups and Qiangji total po lysaccharide nucleoside rats, serum content of TNF rises but this was not statistically significant. Qiangji groups can obviously increase health force serum IL-2 content (P<0.01), the rest of the different degree can b e increased serum IL-2 levels, a statistically significant (P<0.05), Qian gjijiali group can significantly increased IL-6 content (P<0.01), astraga lus membranaceus, Qiangji group total nucleoside total of IL-6 nucleoside group also affect content (P<0.01), but the Qiangji group, astragalus po lysaccharide polysaccharide group no significant changes.Cyclic nucleotides:Compared with the control group, spleen model ra ts plasma cAMP content significantly (P<0.01) elevated, but the content o f cGMP has no obvious changes, cAMP/cGMP ratio also increased (P<0.01), Q iangjijianli can make cAMP content, cAMP/cGMP ratio lower (P<0.01), sligh tly elevated levels cGMP. Astragalus polysaccharide, astragalus nucleosid e and muscle group total polysaccharide group compared with spleen model group cAMP content decreased, cGMP content increased but no statistical s ignificance, astragalus membranaceus polysaccharide and Qiangji polysacch aride cAMP/cGMP ratio lower group (P<0.01). Qiangji group total content o f mangiferin cAMP (P<0.05) cAMP/cGMP ratio lower (P<0.01).Amylase and albumin:spleen model rats, serum amylase and albumin lev els were decreased obviously (P<0.01), Qiangjijianli group, astragalus me mbranaceus polysaccharide, Qiangji polysaccharide, Qiangji groups can mak e amylase total nucleoside and albumin levels have different degrees of i ncreased (P<0.01), especially with Qiangjijianli group for health. And as tragalus can make the total content of mangiferin amylase increased (P<0. 05), albumin levels are increased but this was not statistically signific ant.Pathological morphology change:spleen model group thymus and spleen are pathological changes, protein expression significantly reduce PCNA spleen (P < 0.01). Compared with the spleen, Qiangji jianli group, Qiangji polysaccharide group, Qiangji nucleoside groups can prevent spleen and thymus pathological lesions appear. At the same time, the Qiangjijianli can make PCNA spleen nutrilite protein expression increased (P<0.01), Qiangji polysaccharides and strong muscle of its total glycosides could also improve (P<0.05), but the total polysaccharide and astragalus astragalus nucleoside is not very obvious effect of group (P>0.05),Conclusion: Experiment by filling liquid served rhubarb established spleen decoct ion NEI system disorders, the model of each index all at too higher or to o lower status, and E2 and hormone disorder in the spleen, had appeared in the "spleen and kidney "pathologic states, low immunity. Astragalus tota 1 polysaccharide and astragalus nucleoside as Qiangjijianli of the effect ive components of astragalus gentleman medicine NEI system in the role pl ayed by both similarities and special forces, are not the same. With thei r strong muscle in healthy strength square contains quantity, except for T3, rT3 together, E2, albumin, amylase, has the adjustment of astragalus po lysaccharide focuse on the T4 and TNF, IL-2, Astragalus nucleoside emphasi zed in total with cAMP, IL-2, T, effects of six. Strong muscle strength o f the nutrilite indexes, which can adjust the control that spleen deficie ncy is realized through various channels, astragalus membranaceus polysac charides and astragalus in total also play a nucleoside role, this and th e reuse of astragalus may also have a close relationship.