| Background:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoantibodies production and multisystemic involvement. Environmental and ethnic factors seem to play important roles in the development of the disease. But the exact etiology and pathogenesis is still not clear. The presence of specific autoantibodies are regarded as its prominent features, such as the detection of antinuclear antibodies (ANA), anti double-stranded DNA (dsDNA), anti-Sm, and anti-cardiolipin (aCL) autoantibodies in SLE. Anti-dsDNA antibodies are considered to be pathogenic in systemic lupus erythematosus. Anti-dsDNA antibody is one of specific antibodies for SLE. Previous studies presented a highly variable prevalence ranging from 40% to 98%. More importantly, anti-dsDNA antibodies are considered as one of the American College for Rheumatology (ACR) criteria for the diagnosis of SLE. Anti-dsDNA antibodies not only relate to SLE disease activity, but also play a key role in the pathogenesis of lupus nephritis. Anti-U1RNP antibody may exist in a variety of autoimmune diseases, such as Mixed connective tissue disease(MCTD), Collagen thesaurismosis, Sjogren syndrome, Rheumatoid arthritis, Polymyositis. But it is closely relate to the MCTD, and it is considered a sign antibody of MCTD. Anti-U1RNP antibodies also can present in SLE, the positive rate in SLE is 20-30%. Previous studies show that anti-U1RNP antibodies were associated with Raynaud phenomenon, leukopenia and urine cellular cast.Objectives: This study aims to explore the clinical and serological manifestations of SLE patients and demonstrate the association between anti-dsDNA antibodies, anti-U1RNP antibodies and clinical manifestation, serological features in Chinese population.Methods:Using the questionnaire in the form of collection of clinical data , then entered into a database created using software (EPI INFO, Version 3.1), and transformed to the proper format for analysis using software (SPSS, Version 13.0, SPSS Inc., Chicago, IL).Results: Of the 2,047 SLE patients, there were 1,876 (91.6%) females and 171 (8.4%) males, with a female: male ratio of 11:1. The mean age of the patients was 34.6±12.9 years. The mean age at onset of disease was 31.5±12.3 years. The mean disease duration was 37.5±53.6 months. It showed that the most common initial manifestations of SLE were arthritis (45.8%), malar rash (31.9%) and fever (23.1%). During the evolution of the disease, 64.8% had arthritis, 57.6% renal involvement, and 48.9% malar rash. Anti-dsDNA antibodies were significantly associated with renal involvement, lupus nephritis, serositis, pericarditis and alopecia (P < 0.05, respectively). But it was negatively correlated to photosensitivity (P = 0.011). They were also more likely coexisted with other serological abnormalities including antinuclear antibodies, anti-La/SSB, anticardiolipin IgG and anti-nucleosome antibodies and anti-C1q antibodies, low serum complement C3, C4, elevated IgG and erythrocyte sedimentation rate, leukopenia, lymphocytopenia, anemia, urea nitrogen and urinary parameters (P < 0.05, respectively). However, the cocurrency of anti-RNP were significantly lower in the group with anti-dsDNA antibodies (P = 0.001). Anti-dsDNA antibodies were significantly associated with malar rash, discoid rash, arthritis, renal involvement, raynaud phenomenon, splenohepatomegalia( P < 0.05). Anti-U1RNP antibodies were more likely coexisted with other serological abnormalities including antinuclear antibodies, anti-Sm antibodies, anti SSA antibodies, elevated IgG, IgA and erythrocyte sedimentation rate, low serum complement C4 and elevated urea nitrogen( P < 0.05). Conclusions: Anti-dsDNA antibodies and anti-RNP antibodies are correlated with some clinical and immunological profiles of SLE.
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