Myeloperoxidase Gene -463 G>a Polymorphism And Risk Of Bladder Cancer In Southeast China: A Case-control Analysis

ObjectiveThis study aimed to explore the association between the MPO-463 polymorphism and bladder cancer risk. We hypothesized that this polymorphism may contribute to genetic susceptibility to bladder cancer.MethodsIn a hospital-based case-control study of 355 patients with bladder cancer and 359 cancer-free control subjects frequency-matched by age and sex, we genotyped the MPO polymorphism and analyzed the association with the decreased risk of bladder cancer in Chinese populations.ResultsWe found that individuals with GA/AA genotypes had a significantly decreased risk of bladder cancer (adjusted OR = 0.73, 95% CI: 0.55-0.98) than those with GG genotype. In the stratification analysis, we found that the decreased risk was more pronounced among younger subjects (age≤60 years) (adjusted OR = 0.36, 95% CI: 0.22–0.60), male (adjusted OR = 0.67, 95% CI: 0.46–0.94), smokers (0.63, 0.40-0.98). A statistically significant deceased risk was found in bladder cancer with low but high grades (adjusted OR = 0.69; 95% CI: 0.48-0.96; P = 0.027 for low grade and OR = 0.67, 95% CI: 0.45-0.93, P = 0.029 for high grade). In the stratification of stage, we found that a significantly decreased risk was significant in superficial bladder cancer (OR, 0.61;95% CI, 0.43-0.87; P = 0.006), but no significant associations between the genotypes and invasive bladder cancer were observed (OR, 0.74; 95% CI, 0.49-1.11; P = 0.147).ConclusionsOur data suggests that MPO -463G>A polymorphism may play a role in the etiology of bladder cancer in southern Chinese populations.