| ObjectiveThis study aimed to assess the association between the MIF-173 polymorphism and bladder cancer risk. We hypothesized that this polymorphism may contribute to genetic susceptibility to bladder cancer.MethodsIn a hospital-based case-control study of 325 patients with bladder cancer and 345 cancer-free control subjects frequency-matched by age and sex, we genotyped the MIF polymorphism and analyzed immunohistochemical stained operational bladder cancer tissue sections for MIF.ResultsWe found that individuals with GC/CC genotypes had a significantly decreased risk of bladder cancer (adjusted OR = 0.57, 95% CI, 0.41-0.79) than those with GG genotype. In the stratification analysis, we found that the decreased risk was more pronounced among older subjects (0.56, 0.39-0.81), men (0.47, 0.33–0.68), smokers (0.54, 0.35-0.85), and ever-drinkers (0.44, 0.27-0.71). The percentage of positive staining in the cytoplasm and nucleus in the normal and bladder cancer with CC /GC genotype tissues was higher than that of GG genotype bladder cancer tissue.ConclusionsOur data suggest that MIF -173G>C polymorphism may play a role in the etiology of bladder cancer in southern Chinese populations. |
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