Relation Between Premature Delivery And Vaginal Micro-ecologial Environment

Objective:To investigate the risk factors of premature delivery,in order to provide a screening basis of high-risk group of premature delivery pregnant women for clinical. Methods:retrospective study:Change tendency of preterm birth total and the rate of preterm birth from January of 2004 to December of 2009 in Urumqi Maternal and Child Health Hospital. To investigate main causaes of preterm birth and iatrogenic preterm birth.Take normal term labor cases as control group, To carry out regression analysis screening high-risk factors of preterm birth. Prospective Studie:Adopt bacterial vaginosis(BV) fast kit to screen pregnant women during the second and advanced stage trimester, to probe incidence rate in pregnant women and follow their Pregnancy Outcome. Results:Part 1:retrospective study:1. the rate of preterm birth from 2004 to 2009 each is 6.6%,6.4%,5.4%,6.1%,7.6%,10.5% the rate of preterm birth, doesn't decrease obviously recent years,even show tendency of upgrade. The main first three causes of iatrogenic preterm birth were preeclampsia,vaginal bleeding caused by placenta previa and placental abruption, fetal distress in uterus.2. Anterior preterm birth history, Premature rupture of fetal membranes (PROM), Pregnant-induced hypertension(PIH), Abnormal fetal position,Placenta factors,Multiple or double pregnancies,hydramnios,medical or surgical department complication were the major relevant risk factors of preterm delivery.Part 2:Prospective Study:68 cases with BV patient were checkd out during the 268 second and advanced stage trimester pregnant women. detection rate of Pregnancy combined BV is 25.4%. preterm delivery rate of patient with BV duringgestationalperiod issuper-to normal pregnant moman(p<0.01) effective power of metronidazole is 80.0%. Conclusions:1. the rate of preterm birth, doesn't decrease obviously recent years,even show tendency of upgrade.2. multiple factors all can cause preterm birth, age, anterior preterm birth history, Premature rupture of fetal membranes (PROM), Pregnant-induced hypertension(PIH), Abnormal fetal position, Placenta factors, Multiple or double pregnancies, hydramnios, medical or surgical department complication were the major relevant risk factors of preterm delivery.3. The main first three causes of iatrogenic preterm birth were preeclampsia,vaginal bleeding caused by placenta previa and placental abruption, fetal distress in uterus. The major cause of iatrogenic preterm iatrogenic preterm is different, but they ara homogeneity in preterm etiologically and can't be taken apart completely.4.BV shows correlation with preterm delivery. The incidence of premature delivery in patients with BV were significantly higher than that in normal pregnant women. Treatment to getational pregnant women with BV will have Positive significance for reducing maternal and infant's bad outcome during perinatal period.