Chronic Cerebral Circulation Insufficiency And Brain Tissue Damage And Associated Cognitive Impairment

ObjectBy serum NSE;S100βpeotein in chronic cerebral insufficiency in brain tissue,and chronic cerebral vascular insufficiency and the relationship between cognitive impairment.Methods①Collected from September 2008-December 2009 of qianfoshang Hospital in Shandong Province admissions for patients with chronic cerebral insufficie-ncy 43 cases,24 cases were male, female 19 cases.The average age (65.3±5.8) years.Select the control group over the same period the number of control group 45 cases,24 cases were males,21 cases were female.The average age (65.7±5.3) years.②For all selected patients to exclude the impact to be neuron-specific enolase (NSE) and S100βprotein determination of the outcome of diseases. Application of simple intelligent mental state examination (MMSE) rule out dementia.③Caught all of the above monitor neuron-specific enolase (NSE) in peripheral blood that reflect neuronal damage and S100βprotein (S100(3 protein) in peripheral blood that reflect the excessive inflammatory response of glial cells.All the selected cases apply to Montreal Cognitive Assessment Scale (MoCA), Hamilton Depression Rating Scale (HAMD) examination and Hachinski ischemic scale.ResultsS100βprotein levels in the control group and the CCCI significant difference between groups, NSE levels in the control group and the CCCI was no significant difference between groups. S100βprotein in tissue specificity and high sensitivity, can better reflect brain damage. Long-term, repeated monitoring of blood S100βprotein and attention to the blood content of NSE, compared to a certain extent, reflect the extent of brain damage, which can be insufficient for the diagnosis of chronic cerebral circulation to help.After the Montreal Cognitive Assessment test.patients with chronic cerebral insufficiency, cognitive function than the control group there are different aspects of damage, mainly in visual spatial and executive function, memory and delayed memory, language ability and abstract edge.Conclusion1,In patients with chronic cerebral insufficiency, serum S100βprotein concentrations, serum neuron-specific enolase concentration is not obvious, to monitor their blood concentration can reflect the severity of brain injury.2,Chronic cerebral insufficiency can lead to cognitive impairment, the pathogenesis is more complex,and the brain is closely related to energy metab-olism.3,Chronic cerebral insufficiency in patients with cognitive impairment is not completely consistent, mainly in the visual space implementation capacity, memory and delayed memory, language impairment obvious, but its mechanism is not clear, this article only do explore appropriate.