The Association Between Glucagon Like Peptide-1 And Serum Adiponectin Levels In Obstructive Sleep Apnea-hypopnea Syndrome Patients

Objective:To study the association between Glucagon like peptide-1 and plasma adiponectin level in obstructive sleep apnea-hypopnea syndrome(OSA) patients and investigate the morbidity mechanism of OSA complication glucolipid metabolism disorder.Methods : To select randomly 16 fat adult in examination center as fat control.To select randomly 50 patients with OSA with PSG in sleep detec- tion center , the OSA patients was divided into mild 11 patients, moderate 13 patients and severe 26 patients groups based on the apnea hypopnea index(AHI) and the minimum blood oxygen saturation (SaO_2min). To select 24 patients with simply type 2 diabetes , 14 adults with Simple obesity group and 12 patients with OSA with type 2 diabetes .There is no signify- cant distinction between each interclass and control group in years of age and sexuality . All selected people need to measure the height, weight, to calculate the body mass index (BMI); to carry out polysomnogram monitoring all night for 7 hours at least , analysis apnea hyponea index (AHI)and the minimum O₂ saturation at night ; dividedly collecting 5ml empty stomach peripheral venous blood in two test tube at 6 a.m on next day. Ordinary blood is used to examin fasting plasma glucose(FPG), blood fat and to measure adiponectin by ELISA. Anticoagulated blood is used to detect the level of Glp-1by ELISA.Then anti- coagulated blood is used to extract to detect the level of 1h postpradial Glp-1 by ELISA.Results:1. The levels of GLP-1 in the every group with OSA decreased gradually with AHI.It was significantly higher than that in the mild group(P<0.05).2. The levels of GLP-1 in the severe groups , the patients with OSA with type 2 diabetes and the simple type 2 diabetes group were significantly higher than that in the control group(P<0.05). and that in the severe group was significantly higher than that in the mild group(P<0.05).There was no statistics difference among these patients.3. Adiponectin levels among each group with OSA also have significantly differences (P<0.05) .IN the patients with OSA with type 2 diabetes , the simple type 2 diabetes group and the severe patients with OSA . Adiponectin levels were higher than those in the control group (P<0.05) ; especially in those with OSA with type 2 diabetes .4. GLP-1 was related with adiponectin,AHI,SaO_2min,HbA1c and FPG. Conclusions:1. In patients with OSA , glucolipid metabolic disorder usually appears , including FPG,BMI,HbA1c and the abnormality ofGLP-1, adiponectin.2. The OSA effects surum GLP-1 level .3. OSA may effects surum adiponectin level by the change of surum GLP-1 level .