The Expression And Clinical Significance Of EPO And EPOR In Rectal Cancer

Background and ObjectiveErythropoietin mainly derives its origin from kidney. It is the major hormone that could regulate the red blood cells of precursor proliferation and differentiation and the maintenance of peripheral red blood cell concentrations. In the past scholars believe that the role of erythropoietin is single and now that its role is multifaceted. Studies have shown that erythropoietin and erythropoietin receptor have a certain relationship in the invasion with a variety of malignant tumors now. The EPO and EPOR expression has not reported in rectal cancer yet. In this study, the expression of EPO and EPOR were detected in rectal cancer by immunohistochemical method and to analyze its clinical significance.Materials and MethodsImmunohistochemistry technique was used to detect the expression of EPO and EPOR in 60 cases of rectal cancer and 60 cases of normal rectal tissues. The differences of the two proteins and the correlation of their expression were analyzed in two groups. The relationship of the two proteins and clinicopathological parameters of rectal cancer were analyzed.ResultsThe high expression rate of EPO was 65.0% in rectal cancer tissues, which was 00.0% in normal rectal tissues. The high expression rate of EPO of rectal cancer was significantly higher than the normal rectal group, the difference was statistically significant (P<0.05). The high expression rate of EPO was 40.6% in highly differentiated adenocarcinoma, which was 92.8% in poorly differentiated adenocarcinoma and undifferentiated carcinoma, the difference was statistically significant (P<0.05). According to Dukes stages, the high expression rates of EPO was 35.7% in A and B period, which was 90.6% in C period, the difference was statistically significant (P<0.05). The high expression rate of EPOR was 80.0% in rectal cancer tissues, which was 00.0%in normal rectal tissues. The high expression rate of EPOR in rectal cancer tissue was significantly higher than the normal rectal tissues, the difference was statistically significant (P＜0.05). The high expression rate of EPOR was 65.6% in highly differentiated adenocarcinoma, which was 96.4% in poorly differentiated adenocarcinoma and undifferentiated carcinoma, the difference was statistically significant(P<0.05). According to Dukes stages, the high expression rates of EPOR was 64.3% in A and B period, which was 93.8% in C period, the difference was statistically significant (P<0.05). The related analysis of EPO and EPOR expression in rectal cancer showed that EPO and EPOR was positive correlation (R=0.419, P=0.004). The correlation was statistically significant.ConclusionThe levels of EPO and EPOR expression of rectal cancer tissues is significantly higher than the normal rectal tissues; The levels of EPO and EPOR expression correlate with tumor differentiation and Dukes stage, EPO and EPOR expression is positively correlated.