Expression Of PDCD5, Survivin, Tip60 And P53 Protein And Their Significance In CIN And Cervix Cancer

Objective:To study the relationship of the expressions of PDCD5, Survivin, Tip60 and p53 in CIN and cervix cancer. Methods:The expression of PDCD5, Survivin, Tip60 and p53 was examined by immunohistochemical in 49 CIN,39 cervical carcinomas and 20 normal cervix tissues. Results:1)The positive expression of PDCD5 was 100%,100%, 81.25%,61.11%,10.25%, in normal cervix tissues CINⅠ,Ⅱ,Ⅲand cervical carcinoma respectively, and the difference was statistically significant。normal cervix tissues and CINⅠ, CINⅡand CINIII there was no obvious difference. The positive expression rate of PDCD5 protein in esophageal carcinoma was significantly correlated with tumor differentiation(P<0.05); 2)The positive expression of Survivin was 0,40%,50%,72.22%,82.05%, in normal cervix tissues, CINⅠ,Ⅱ,Ⅲand cervical carcinoma respectively, in normal cervix tissues CIN and cervical carcinoma respectively, and the difference was statistically significant。CINⅠand CINⅡ, CINⅢand cervical carcinoma there was no obvious difference.Significant survivin expression was noted in cancer patients with lymph node metastasis(P<0.01)and the clinicopat hological types(P<0.05); 3)The positive expression of Tip 60 was 65%,60%,75%,72.22%,76.92%, in normal cervix tissues, CINⅠ,Ⅱ,Ⅲand cervical carcinoma respectively, normal cervix tissues,CINⅠ-Ⅲand cervical carcinoma there was no obvious difference; 4)The positive expression of p53 was 61.53% in cervical carcinoma, in normal cervix tissues negative, the difference was statistically significant; 5)The expression of Tip60 was positively correlated with p53 protein.Conclusion:Expression of PDCD5,Survivin, Tip 60 and p53 abnormal expression of them may be involved in the occurrence and development of cervical cancer. It was speculated that there may be a common transcription mechanism which constructed multiple pathways in cancer.