Expression Of Survivin And PDCD5 Protein And Their Significance In Mucoepidermoid Carcinoma

Objective:To investigate the expression of the apoptosis-related protein of Survivin and PDCD5 in normal parotid tissue, pleomorphic adenoma tissue and mucoepidermoid carcinoma tissue and to find out their relationship with the biologic behavior of mucoepidermoid carcinoma tissue.Methods:Survivin(Inhibitor of apoptosis protein) and PDCD5(pro-apoptotic protein) were detected by immunohistochemical (Elivision) staining in 10 cases of normal parotid tissues,40 cases of pleomorphic adenoma tissues and 45 cases of mucoepidermoid carcinoma tissues.Results:(1)The expression levels of Survivin protein was increased in the order of normal parotid tissues-pleomorphic adenoma tissues-mucoepidermoid carcinoma tissues,but PDCD5 protein was decreased relatively. The expression rate of Survivin protein was 10%,27.5% and 55.6%(x2=14.556),while the rate of PDCD5 protein was 85%?65% and 33.3% (x2=17.439)in normal parotid tissue, pleomorphic adenoma tissue and mucoepidermoid carcinoma tissue,respectively. The expression rates of Survivin protein and PDCD5 protein were significantly different among the normal parotid tissue, pleomorphic adenoma tissue and mucoepidermoid carcinoma tissue (P <0.01). The difference of three gruops has obvious statistical significance.(2)The expression rate of Survivin protein and PDCD5 protein was related with differentiation,Lymph node metastasis and tumer TNM staging, and with other clinicopathological parameters was no obvious correlation.(3)The expression rate of Survivin protein and PDCD5 protein showed a negative correlation in mucoepidermoid carcinoma tissue(x2=4.500,?s=-0.316). The difference of three gruops has obvious statistical significance(P=0.034<0.05).Conclusion:Survivin protein does over-express in the mucoepidermoid carcinoma tissues, however PDCD5 protein does low-express relatively. Varying degrees of the expression of Survivin protein and PDCD5 protein are closely associated with the occurrence and development of mucoepidermoid carcinoma and may be applied as a new target for therapy,monitoring,early screening,diagnosis and prognosis of mucoepidermoid carcinoma tissues.