The Clinical Effect And Safety Of Extracts Of Solanum Nigrum Combined With The VAD Regimen In Treatment Of Multiple Myeloma

Objective:To evaluate the clinical effect and safety of extracts of Solanum nigrum combined with the VAD regimen in treatment of multiple myelomaMethods:60 patients were randomly divided into two groups.The experimental group of 30 patients was treated with the VAD regimen combined with extracts of Solanum nigrum and the controls of 30 patients were treated using the VAD regimen only.Before and after treatment were compared to patients with the clinical symptoms,the proportion of cancer cells,immune globulin,erythrocyte sedimentation rate,β2-microglobulin,ECG,as changes in the peripheral blood toxicity and the emergence of the situation.Results:Compared with the control group,the total effective rate of Traditional Chinese Medicine in the experimental group was 93.33%and that in the control group was 60.00%,which was significantly different between the experimental group and control group(P=0.004<0.05).The proportion of cancer cell immune globulin,erythrocyte sedimentation rate,β2-microglobulin after treatment were significantly different between the experimental group and control group(P<0.05)。There was no significant difference in WBC,AST,serum calcium,ECG,toxicity after treatment(P>0.05)。Conclusion:Extracts of Solanum nigrum combined with the VAD regimen can effectively reduce tumor burden of patients of multiple myeloma,levels of serum M protein and improve significantly the effective rate of Traditional Chinese Medicine,whose total effective rate outweigh the control group andtoxicity isn,t reduced after treatment, which can be adopted widely。...