Preparation Of Poly "3-(Trimethoxysilyl) Propyl Methacrylate-Co-2-(Methacryloyloxy) Ethyl 2-(Trimethylammonio) Ethyl Phosphate" Via Atrp And Studies Of It's Blood Anticoagulation Activity

Biological materials have been widely used in biomedical fields, such as artificial organs, and various diagnostic, Medical Devices and so on Biocompatibility, particularly blood compatibility, is the most important property required for biomedical materials, To improve blood compatibility of biomaterials is always an important research task for biomaterial research and development.Attention has been paid to making polymeric materials for biomedical applications for more than 50 years, only three type antithrombogenic biomaterials such as PEO chain structure, phospholipid polymers and surface heparinized biomaterials were considered better. But their blood compatibility is still not adequate for the more demanding applications.Grafting molecules with special structure onto the polymer surface of proper mechanical property can give polymer new surface properties while keeping its mechanical properties and it is an important way to develop new biomaterials.In this research work, according to the hypothesis of "Maintain of normal structure", a macroinitiator of Poly3-(Trimethoxysilyl)propyl methacrylate-Br was preparaed. Then it was used to prepare the copolymer of 3-(Trimethoxysilyl)propyl methacrylat(TMSPMA) and 2-(Methacryloyloxy)ethyl 2-(Trimethylammonio)ethyl Phosphate(MPC) via ATRP. Gel Permeation Chromatog-raphy(GPC) and Hydrogen Nuclear Magnetic Resonance(HNMR) were used to test the product and study the reaction kinetics.We also used this copolymer to modify the membranes of cellulose and silicone rubber.The result of the modification suggested good blood anticoagulation activity via the tests of static contact angle and platelet adsorption...