Clinical Study Of HPA Axis Function In Patients With T2DM And Exprimental Exploration Of The New Pathway Of Pharmacotherapy

Objective:1. To explore the status of the HPA axis functions and the relationship between the function of HPA axis and glycometabolism, lipid metabolism in patients with type 2 diabetes.2. To compare the factors related to HPA axis functions in patients with type 2 diabetes on the different grade levels of HbA1c, and explore the effect of long-term different glucose level on the HPA axis function in patients with type 2 diabetes.3. To study the fuction changes of HPA axis and possible potencial risk factors in patients with type 2 diabetes combined hypertension.4. To investigate the effect of intervention methods on glucose and lipid metabolism in type 2 diabetes rat model based on HPA axis, and to be explored the mechanism of action preliminary.Methods:1. The data of 75 cases of type 2 diabetes and 30 cases of healthy volunteers were collected. The blood samples were collected, and the serum FBS, FINS, C-P, HbA1c and plasma lipid level including TC, TG, HDL-C, LDL-C, apoA1, apoB, apo A1/B, as well as cortisol, ACTH, CRH levels were assayed All of these data were computed with statistics.2. SBP, body height, weight and the BMI of 147 cases of patients with type 2 diabeties were measured and accounted Blood samples were collectd, and the serum FBS, FINS, C-P, HbA1c, plasma lipid level including TC, TQ HDL-C, LDL-C, apoA1, apoB, apoA1/B, LP(a), as well as the levels of cortisol, ACTH, CRH were assayed All of the data were computed with statistics. Based on the HbA1c level, all patients were divided into three groups:high HbA1c (HH) group (HbA1c>11%), midium HbA1c (MH) group (7%