| Diabetes is a common and frequently occurring disease in clinic. And it can heavily influence people's work and living. In recent years, the incidence of diabetes is increasing year after year along with our country's national income enhance fleetly, resident standard of living improved constantly, the changing of people's life style, and living pressure increase continually. Average people and medical affairs operator are more and more attach importance to diabetes than before. At present, the sugar reducing medicine commonly used in clinical practice has definitely and affirmatively curative effect in controlling blood sugar. At the same time, Western medicine has its disadvantage, for instance, badly effect in improving symptom and huge side-effect. However, Traditional Chinese Medicine (abbreviation: TCM) has its own unique advantage, for example, improving diabetes sufferer symptom and enhancing their living quality, prevent and cure subsequent disease of diabetes. Therefore, the research of how to prevention and cure diabetes has become an important thing, especially in researching and exploring new medicine for diabetes under the guidance basic theory of TCM. This work has significant practical meaning and clinical application value.There are three parts in the thesis: document reviews, theoretic research and clinical research.Document reviews: At first, we summarized current mainstream viewpoint of TCM about diabetes's pathogenesis key at yin-deficiency and dryness-heat, its primary therapeutic model is Sanxiaofenzhi. And then we discourse upon Diabetes's deferent treatment theory and method from ancient to modern. For example, Diabetes treated according the location of disease (including Diabetes treated according the liver or spleen or kidney or heart or several organs) or Causes and pathological products (including Diabetes treated according phlegm-dampness or blood stasis or poison or Qi), and others treatment method (For instance, Diabetes treated according Xuanfu.)Theoretic research: We explained the relation between traditional theory of "Open, Close and Axis" and diabetes. The theory of "Open, Close and Axis" originated from inner Canon of Yellow Emperor. Original concept of "Open, Close and Axis" is a kind of description to door's structure and functions. Inner Canon of Yellow Emperor developed it to the theory of Yang's ascending, descending, exiting and entering. People's Yang ascends, descends, exits and enters at body's doors, and its working mechanism is "Open, Close and Axis". Everybody have two doors, one is yang door that is at body's surface layer, another is yin door that is at body's deep level. The two doors have its own "Open, Close and Axis". Taiyang is Open, yangming is Close and shaoyang is Axis at yang door. Taiyin is Open, jueyin is Close and shaoyin is Axis at yin door. The "Open, Close and Axis"at yang door and yin door is to be decided by yang's ascending, descending, exiting and entering. It is because that yang is magistral between yin and yang. Yang is leader and yin is attendant. We discoursed that the functional characteristicof "Open, Close and Axis". Open is primary ascending and exiting. Close is primary descending and entering. Axis is the adjustor between Open and Close. "Open, Close and Axis" are uniform , integrated, interactive , compatible as a whole. The theory of "Open, Close and Axis" was developed and applied on the treatise on febrile and miscellaneous disease. We expatiate functional characteristics and the relationship among the three of "Open, Close and Axis". And then we explained the essential and its clinical manifestations of the theory of "Open, Close and Axis". Every people have two Axis. Shaoyang is Yang Axis and it responsible for Yang's ascending, descending, exiting and entering at shallow layers. Shaoyin is Yin Axis and it responsible for Yang's ascending, descending, exiting and entering at deep layer. Shaoyang and Shaoyin contacts closely and interact reciprocally in physiological effects. Shaoyang and Shaoyin influence mutual in pathological changes. In the treatise on febrile and miscellaneous disease, Xiaochaihutang is the primary prescription of Yang Axis's dysfunction, Sinisan is the primary prescription of Yin Axis's dysfunction. We expound the compositive principle and clinical applications of Xiaochaihutang and Sinisan. We bring forward a point of view: Chaihu is the best medicine of mediating Axis's functions. According to 8 sides arguments, we made a conclusions that the occurrence and deterioration of diabetes is closely related to "Open, Close and Axis" dysfunction. According to academician Wangyongyan's experiences in clinical and scientific research, his viewpoint about the key causes of diabetes is Axis's dysfunction. Along with deferent diabetes periods, Axis's dysfunction has deferent emphases. In early and metaphase period, the emphase is Shaoyang Axis's dysfunction. In late stage, the emphase is Shaoyin Axis's dysfunction. So, mediating Shaoyang Axis and Shaoyin Axis is the key of treatment. When the Axis's dysfunction is improved, the diabetes sufferer's sufferings are alleviated. Academician Wang invent the prescription of Chaihutiaoshutang. Chaihutiaoshutang is based on Xiaochaihutang and Sinisan and tie in academician Wang's clinical experiences. By the clinical applications of Chaihutiaoshutang, we found that it has great curative effect.Clinical research: We evaluated on clinical curative effects and security of Chaihutiaoshutang for diabetes. In the research, 64 cases were allocated to treatment group (32 cases) and control group (32 cases) randomly. The treatment group were received a treatment on the base by adding or reducing drugs of Chaihutiaoshutang and metformin, the control group only received metformin. After 8 weeks, we observed the changes of fasting blood glucose, postprandial 2 hours blood glucose, glycosylated hemoglobin, blood routine examination, urine routine examination, stool routine examination, function examination of liver and kidney and Electro cardiograph, TCM symptom. By Ridit test and of the variance analysis repeated measure, we found that the effect of treatment group is better than control group's at the level of fasting blood glucose, postprandial 2 hours blood glucose, TCM syndrome, diseases efficacy. There are no deference at glycosylated hemoglobin between the treatment group and control group. By comprehensive analysis, we believe that the effect of Chaihutiaoshutang and metformin is better than metformin;s at subjective and objective symptoms of patients. There are no side-effects in the clinical research. The study indicates that Chaihutiaoshutang based on the theory of "Open, Close and Axis" is effective and secure in treating diabetes.We made series of conclusions that the idea of Yang is leader and Yin is assistant is the key to traditional Chinese culture and TCM. The theory of "Open, Close and Axis" is the importent theory to research life and treat diseases. The key to diabetes is Axis 's dysfunction. The symptoms of Shaoyang Axis dysfunction and Shaoyin Axis dysfunction is complicated and duality. The key construction to diabetes of Chaihutiaoshutang is point to Yang and Axis.We firstly introduced the theory of "Open, Close and Axis" into diabetes's clinical research. We emphasized the role of Yang in traditional Chinese culture and TCM. Our research deepen the understanding to pathogenesis of diabetes, offer a new pathway for clinical therapy, blazed new trails and enrich the doctrines of pathogenesis and therapy.
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